⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL113085 | 0.81 | — | — | |
| SCHEMBL171325 | 0.81 | — | — | |
| SCHEMBL29845083 | 0.75 | — | — | |
| SCHEMBL2034856 | 0.75 | — | — | |
| SCHEMBL246058 | 0.74 | — | — | |
| SCHEMBL786227 | 0.74 | — | — | |
| SCHEMBL29364638 | 0.74 | — | — | |
| SCHEMBL654863 | 0.74 | — | — | |
| SCHEMBL32457366 | 0.74 | — | — | |
| SCHEMBL687645 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 352 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117624133-A | Dihydroquinoline derivative and application thereof in lung cancer treatment | 重庆三峡医药高等专科学校 | 2024-03-01 | — | — | CN | claimed |
| CN-106478519-B | A kind of preparation method of 2- methyl -4- amino -6- chlorine pyrimidine | 上海再启生物技术有限公司 | 2018-12-11 | — | — | CN | claimed |
| CN-106543089-A | A kind of synthetic method of Dasatinib intermediate | 山东铂源药业有限公司 | 2017-03-29 | — | — | CN | claimed |
| CN-106478519-A | A kind of preparation method of 2 methyl, 4 amino, 6 chlorine pyrimidine | 上海再启生物技术有限公司 | 2017-03-08 | — | — | CN | claimed |
| EP-4308096-B1 | HETEROAROYL AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | MERCK SHARP & DOHME LLC (US) | 2026-05-13 | — | — | EP | disclosed |
| EP-4676923-A1 | BIARYLAMIDE DERIVATIVES AND THEIR USE AS PKMYT1 INHIBITORS | Cancer Research Technology Limited (GB) | 2026-01-14 | — | — | EP | disclosed |
| US-20250243193-A1 | AMIDE-SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | SYNGENE INTERNATIONAL LIMITED (IN) | 2025-07-31 | — | — | US | disclosed |
| US-12312339-B2 | Polo like kinase 4 inhibitors | ORIC PHARMACEUTICALS, INC. (US) | 2025-05-27 | — | — | US | disclosed |
| US-20240308980-A1 | HETEROARYL AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | MERCK SHARP & DOHME LLC (US) | 2024-09-19 | — | — | US | disclosed |
| WO-2024184550-A1 | BIARYLAMIDE DERIVATIVES AND THEIR USE AS PKMYT1 INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-09-12 | — | — | WO | disclosed |
| US-20240270722-A1 | POLO LIKE KINASE 4 INHIBITORS | ORIC PHARMACEUTICALS, INC. | 2024-08-15 | — | — | US | disclosed |
| US-20240226106-A1 | INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES (US) | 2024-07-11 | — | — | US | disclosed |
| EP-0422178-B1 | PYRIMIDINE DERIVATIVES | ZENECA LTD (GB) | 1994-10-05 | — | — | EP | disclosed |
| CN-1024793-C | Pyrimiding derivatives | ICI PLC (GB) | 1994-06-01 | — | — | CN | disclosed |
| US-5223505-A | PYRIMIDINE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-29 | — | — | US | disclosed |
| EP-0422178-A1 | PYRIMIDINE DERIVATIVES. | ICI PLC (GB) | 1991-04-17 | — | — | EP | disclosed |
| US-5002949-A | Anticoagulants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-03-26 | — | — | US | disclosed |
| CN-1047080-A | Pyrimidine derivatives | ICI PLC (GB) | 1990-11-21 | — | — | CN | disclosed |
| WO-1990012790-A1 | PYRIMIDINE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-11-01 | — | — | WO | disclosed |
| EP-0019811-A1 | Pyrimidine compounds, process for their preparation, pharmaceutical compositions containing them and their therapeutical use | CIBA-GEIGY AG (CH) | 1980-12-10 | — | — | EP | disclosed |