⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL786227 | 0.85 | — | — | |
| SCHEMBL28417512 | 0.84 | KMT2A (0.38) | — | |
| SCHEMBL13485361 | 0.81 | — | — | |
| SCHEMBL4970873 | 0.81 | — | — | |
| SCHEMBL115697 | 0.81 | — | — | |
| SCHEMBL1671480 | 0.81 | — | — | |
| SCHEMBL13501656 | 0.81 | — | — | |
| SCHEMBL18971574 | 0.79 | ALDH1A1 (0.46) | — | |
| SCHEMBL20840575 | 0.79 | ALDH1A1 (0.50) | — | |
| Hydrochloric Acid SCHEMBL11187707 | 0.79 | NPC1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1276 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118702686-A | Flavonoid derivative and preparation method and application thereof | 九江学院 | 2024-09-27 | — | — | CN | claimed |
| CN-115197201-B | Chrysin derivative containing aminopyrimidine ring as well as preparation method and application thereof | 九江学院 | 2023-12-26 | — | — | CN | claimed |
| CN-115197201-A | Chrysin derivative containing aminopyrimidine ring and preparation method and application thereof | 九江学院 | 2022-10-18 | — | — | CN | claimed |
| CN-115050893-A | Perovskite solar cell based on alkaloid additive | 安徽大学 | 2022-09-13 | — | — | CN | claimed |
| CN-113024536-B | 5-aminothiazole methanamide compound containing pyrimidine-piperazine ring and preparation method and application thereof | 湖南师范大学 | 2022-05-27 | — | — | CN | claimed |
| CN-109796448-B | Preparation process of dasatinib | 山东罗欣药业集团股份有限公司 | 2022-05-10 | — | — | CN | claimed |
| CN-113767925-A | Bactericidal composition containing captan and cymoxanil and preparation method thereof | 毅植农业科技有限公司 | 2021-12-10 | — | — | CN | claimed |
| CN-113024536-A | 5-aminothiazole methanamide compound containing pyrimidine-piperazine ring and preparation method and application thereof | 湖南师范大学 | 2021-06-25 | — | — | CN | claimed |
| CN-109678853-B | Preparation process of dasatinib | 山东罗欣药业集团股份有限公司 | 2020-09-11 | — | — | CN | claimed |
| CN-109503568-B | Preparation method of dasatinib | 山东罗欣药业集团股份有限公司 | 2020-08-07 | — | — | CN | claimed |
| WO-2015049645-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF DASATINIB | ALEMBIC PHARMACEUTICALS LIMITED (IN) | 2015-04-09 | — | — | WO | claimed |
| US-20150057446-A1 | PROCESS FOR PREPARING DASATINIB MONOHYDRATE | SHILPA MEDICARE LTD (IN) | 2015-02-26 | — | — | US | claimed |
| WO-2013157019-A2 | PROCESS FOR PREPARING DASATINIB MONOHYDRATE | SHILPA MEDICARE LTD. (IN) | 2013-10-24 | — | — | WO | claimed |
| CN-102161660-A | Preparation method of 2-(6-chloro-2-methylpyrimidinyl-4-amino)-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide | INST MATERIA MEDICA CAMS | 2011-08-24 | — | — | CN | claimed |
| US-7932386-B2 | Preparation of 2-amino-thiazole-5-carboxylic-acid derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-04-26 | — | — | US | claimed |
| EP-1919885-B1 | PREPARATION OF 2-AMINO-THIAZOLE-5-CARBOXYLIC-ACID DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2010-04-28 | — | — | EP | claimed |
| US-20090030203-A1 | PREPARATION OF 2-AMINO-THIAZOLE-5-CARBOXYLIC-ACID DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-01-29 | — | — | US | claimed |
| EP-1919885-A1 | PREPARATION OF 2-AMINO-THIAZOLE-5-CARBOXYLIC-ACID DERIVATIVES | Brystol-Myers Squibb Company (US) | 2008-05-14 | — | — | EP | claimed |
| WO-2007019210-A1 | PREPARATION OF 2-AMINO-THIAZOLE-5-CARBOXYLIC-ACID DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-15 | — | — | WO | claimed |
| US-20070037978-A1 | Amidating chloro-, methyl-, methoxy, ethyl- or ethoxy-substituted aniline with 2,3-dichloroacryloyl chloride, alkanoate salt and inorganic base to form an N-phenyl-2-chloro-3,3-dimethoxypropionamide (that is also claimed), which is reacted with thiourea to form a N-phenyl-2-aminothiazol-5-ylcarboxamide | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-15 | — | — | US | claimed |