SCHEMBL11575864

SCHEMBL11575864

O=C1Cc2cc(F)ccc2Oc2ccccc21

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAOB P27338 8/20 0.42
MAOA P21397 1/20 0.40
STK17B O94768 1/20 0.40
CYP19A1 P11511 4/20 0.38
BCHE P06276 1/20 0.37
CES1 P23141 1/20 0.37
PARP1 P09874 1/20 0.37
EPHX2 P34913 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA4 P22748 1/20 0.36
CA6 P23280 1/20 0.36
MEN1 O00255 1/20 0.36
GAA P10253 1/20 0.36
CASP6 P55212 1/20 0.36
KMT2A Q03164 1/20 0.36
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
HPGD P15428 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5642473 0.88 MAOB (0.48) MAOBMAOASTK17BCYP19A1BCHE
SCHEMBL11454990 0.84 MAOB (0.48) MAOBMAOABCHECES1PARP1
SCHEMBL4427203 0.81 MAOA (0.61) MAOBMAOASTK17BCYP19A1BCHE
SCHEMBL11579332 0.81 NPC1 (0.54) MAOBMAOABCHECES1PARP1
SCHEMBL11576876 0.81 AHR (0.49) MAOBMAOACYP19A1BCHECES1
SCHEMBL11564826 0.81 MAPK1 (0.47) MAOBMAOAMEN1KMT2AKDM4E
SCHEMBL5783916 0.80 MAOA (0.65) MAOBMAOAEPHX2CA1CA2
SCHEMBL7112746 0.79 NOTUM (0.36) MAOBSTK17BEPHX2MEN1GAA
SCHEMBL11577383 0.79 HRH4 (0.46) MAOBMAOACYP19A1CA2GAA
SCHEMBL11577980 0.79 MAOB (0.40) MAOBMEN1GAAKMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4118572-A CNS DEPRESSANTS, NEUROLEPTIC AGENTS, SCHIZOPHRENIA, TRANQUILIZERS HOFFMANN-LA ROCHE INC. (US) 1978-10-03 US disclosed
US-4105664-A Dibenz[b,f]oxepin derivatives HOFFMANN-LA ROCHE INC. (US) 1978-08-08 US disclosed
US-4100173-A DEPRESSANTS, SCHIZOPHRENIA, TRANQUILIZERS HOFFMANN-LA ROCHE INC. (US) 1978-07-11 US disclosed
US-4091023-A ANTISCHIZOPHRENIA AGENTS, TRANQUILIZERS HOFFMANN-LA ROCHE INC. (US) 1978-05-23 US disclosed
US-4032525-A CNS DEPRESSANTS, NEUROLEPTICS HOFFMANN-LA ROCHE INC. (US) 1977-06-28 US disclosed