Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.42 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2698252 | 0.98 | TSHR (0.55) | TSHRTAAR1NR1H2NR1H3CNR2 | |
| Iodide SCHEMBL11574871 | 0.94 | TSHR (0.52) | TSHRTAAR1NR1H2NR1H3CNR2 | |
| SCHEMBL4481666 | 0.92 | TSHR (0.53) | TSHRTAAR1CNR2KCNH2CHRM2 | |
| SCHEMBL16294617 | 0.90 | TSHR (0.52) | TSHRTAAR1CNR2KCNH2 | |
| SCHEMBL10786663 | 0.90 | TSHR (0.52) | TSHRTAAR1CNR2KCNH2 | |
| SCHEMBL21917084 | 0.90 | TSHR (0.52) | TSHRTAAR1CNR2KCNH2 | |
| SCHEMBL10490441 | 0.90 | TSHR (0.52) | TSHRTAAR1CNR2KCNH2 | |
| SCHEMBL4342408 | 0.90 | TSHR (0.52) | TSHRTAAR1CNR2KCNH2 | |
| SCHEMBL8065394 | 0.90 | TSHR (0.52) | TSHRTAAR1CNR2KCNH2 | |
| SCHEMBL27372199 | 0.90 | TSHR (0.52) | TSHRTAAR1CNR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4124630-A | Process for the production of chloromethyl thiocyanate | OFFERMANNS HERIBERT | 1978-11-07 | — | — | US | disclosed |