Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11580341 | 0.99 | KDM4E (0.49) | KDM4EMAPTMAPK1MEN1KMT2A | |
| SCHEMBL11577952 | 0.86 | ALDH1A1 (0.52) | KDM4EMAPTMAPK1KMT2APDE4B | |
| Hydrochloric Acid SCHEMBL11576904 | 0.85 | ALDH1A1 (0.51) | KDM4EMAPTMAPK1KMT2APDE4B | |
| SCHEMBL11580232 | 0.80 | SMN1; SMN2 (0.55) | KDM4EMAPTMAPK1KMT2APDE4B | |
| SCHEMBL11576284 | 0.80 | PDE4A (0.55) | KDM4EPDE4BALDH1A1SMN1; SMN2PDE4A | |
| SCHEMBL11577001 | 0.79 | ALDH1A1 (0.45) | KDM4EMAPTMAPK1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11575103 | 0.79 | SMN1; SMN2 (0.54) | KDM4EMAPTMAPK1KMT2APDE4B | |
| Hydrochloric Acid SCHEMBL11578577 | 0.79 | PDE4A (0.54) | KDM4EPDE4BALDH1A1SMN1; SMN2PDE4A | |
| Hydrochloric Acid SCHEMBL11580337 | 0.78 | ALDH1A1 (0.44) | KDM4EMAPTMAPK1MEN1KMT2A | |
| SCHEMBL11577500 | 0.78 | KDM4E (0.48) | KDM4EMAPTMAPK1PDE4BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4015006-A | 3(2H)-Isoquinolones therapeutic process | MEAD JOHNSON & COMPANY (US) | 1977-03-29 | — | — | US | claimed |
| US-4075344-A | 3-ALKOXYISOQUINOLINES FOR HYPOTENSIVE AND VASODILATING EFFECTS | MEAD JOHNSON & COMPANY (US) | 1978-02-21 | — | — | US | disclosed |