Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.61 |
| ▸ | HRH1 | P35367 | 1/20 | 0.61 |
| ▸ | HTR2B | P41595 | 1/20 | 0.61 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28848601 | 0.80 | SLC6A4 (0.67) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL73498 | 0.80 | SLC6A4 (0.67) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL5873468 | 0.76 | SLC6A4 (0.61) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL3011129 | 0.76 | SLC6A4 (0.61) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL8851612 | 0.76 | SLC6A4 (0.61) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| Chlorphentermine SCHEMBL160516 | 0.76 | SLC6A2 (1.00) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL9479412 | 0.76 | SLC6A4 (0.61) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL2823833 | 0.76 | SLC6A4 (0.55) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL6825275 | 0.76 | SLC6A4 (0.55) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL11670635 | 0.74 | SLC6A4 (0.59) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4073941-A | Aralkyl amides having antidepressive activity | ASTRA LAKEMEDEL AKTIEBOLAG (SW) | 1978-02-14 | — | — | US | disclosed |