Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.81 |
| ▸ | MAOA | P21397 | 1/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.59 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.57 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | MPO | P05164 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL8769245 | 0.91 | MEN1 (0.74) | MEN1KMT2ATDP1MAOACHRM2 | |
| Acetic Acid SCHEMBL4203427 | 0.91 | MEN1 (0.74) | MEN1KMT2ATDP1MAOACHRM2 | |
| Bicarbonate SCHEMBL11577277 | 0.90 | HDAC8 (0.64) | MEN1KMT2ATDP1MAOACHRM2 | |
| Bicarbonate SCHEMBL23420914 | 0.90 | HDAC8 (0.64) | MEN1KMT2ATDP1MAOACHRM2 | |
| SCHEMBL5764 | 0.90 | MEN1 (1.00) | MEN1KMT2ATDP1MAOACHRM2 | |
| Bicarbonate SCHEMBL11575509 | 0.89 | GAA (0.80) | MEN1KMT2ATDP1MAOACHRM2 | |
| Water SCHEMBL4230715 | 0.87 | MEN1 (0.94) | MEN1KMT2ATDP1MAOACHRM2 | |
| SCHEMBL4913828 | 0.87 | MEN1 (0.94) | MEN1KMT2ATDP1MAOACHRM2 | |
| SCHEMBL5040570 | 0.87 | MEN1 (0.94) | MEN1KMT2ATDP1MAOACHRM2 | |
| SCHEMBL4922899 | 0.87 | MEN1 (0.94) | MEN1KMT2ATDP1MAOACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4097665-A | Diacylnucleosides and process for preparing the same | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JA) | 1978-06-27 | — | — | US | disclosed |