Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 12/20 | 1.00 |
| ▸ | NPC1 | O15118 | 9/20 | 1.00 |
| ▸ | RAB9A | P51151 | 9/20 | 1.00 |
| ▸ | HPGD | P15428 | 7/20 | 0.75 |
| ▸ | POLB | P06746 | 2/20 | 0.75 |
| ▸ | MAPT | P10636 | 8/20 | 0.73 |
| ▸ | TP53 | P04637 | 4/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.69 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.69 |
| ▸ | RELA | Q04206 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | CCR6 | P51684 | 1/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1719961 | 0.89 | SMN1; SMN2 (0.79) | SMN1; SMN2NPC1RAB9AHPGDPOLB | |
| SCHEMBL31500060 | 0.81 | SMN1; SMN2 (0.69) | SMN1; SMN2NPC1RAB9AHPGDPOLB | |
| SCHEMBL10542264 | 0.81 | NPC1 (0.69) | SMN1; SMN2NPC1RAB9AHPGDPOLB | |
| SCHEMBL8765128 | 0.80 | SMN1; SMN2 (0.67) | SMN1; SMN2NPC1RAB9AHPGDPOLB | |
| SCHEMBL2461662 | 0.79 | SMN1; SMN2 (0.66) | SMN1; SMN2NPC1RAB9AHPGDPOLB | |
| SCHEMBL34059 | 0.79 | SMN1; SMN2 (0.72) | SMN1; SMN2NPC1RAB9AHPGDPOLB | |
| SCHEMBL4748541 | 0.79 | SMN1; SMN2 (0.65) | SMN1; SMN2NPC1RAB9AHPGDPOLB | |
| SCHEMBL3683981 | 0.79 | RAB9A (0.65) | SMN1; SMN2NPC1RAB9AHPGDPOLB | |
| SCHEMBL11648402 | 0.79 | NPC1 (0.65) | SMN1; SMN2NPC1RAB9AHPGDPOLB | |
| SCHEMBL14132909 | 0.79 | SMN1; SMN2 (0.65) | SMN1; SMN2NPC1RAB9AHPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120302581-A1 | Methods and Compositions for the Treatment of RAS Associated Disorders | THE TRUSTEES OF DARTMOUTH COLLEGE | 2012-11-29 | — | — | US | disclosed |
| US-20120302581-A1 | Methods and Compositions for the Treatment of RAS Associated Disorders | THE TRUSTEES OF DARTMOUTH COLLEGE | 2012-11-29 | — | — | US | disclosed |
| US-4113718-A | Basic azo dyes | CIBA-GEIGY CORPORATION (US) | 1978-09-12 | — | — | US | disclosed |
| US-4113731-A | PHOTOGRAPHIC EMULSION STABILIZERS | GRUPPO LEPETIT S.P.A. (IT) | 1978-09-12 | — | — | US | disclosed |
| US-4006127-A | Cationic diazacyanine dyestuffs | BAYER AKTIENGESELLSCHAFT (DT) | 1977-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302581-A1 | Methods and Compositions for the Treatment of RAS Associated Disorders | NRAS, HRAS, KRAS | SMN1; SMN2 1031/4885NPC1 2089/4885RAB9A 596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.