SCHEMBL11580962

SCHEMBL11580962

CN1CCC(C(Cl)Cl)C1=O

nearest known ligand 0.35

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.35
PIK3CD O00329 1/20 0.31
BRD4 O60885 1/20 0.30
BRD2 P25440 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2032853 0.82 MAPK1 (0.35) MAPK1PIK3CDBRD4BRD2
SCHEMBL9251987 0.79 MAPK1 (0.37) MAPK1PIK3CDBRD4BRD2
SCHEMBL18883353 0.79 MAPK1 (0.37) MAPK1PIK3CDBRD4BRD2
SCHEMBL18821187 0.79 MAPK1 (0.37) MAPK1PIK3CDBRD4BRD2
SCHEMBL23108901 0.76 MAPK1 (0.34) MAPK1PIK3CDBRD4BRD2
SCHEMBL23480323 0.76 ACE (0.35) MAPK1BRD4
SCHEMBL17572147 0.71
SCHEMBL9825169 0.71
SCHEMBL146924 0.69
SCHEMBL23631117 0.69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10479819-B2 Oxyntomodulin analogue JIANG, Xianxing (CN) 2019-11-19 US disclosed
US-20190002444-A1 CRYSTALLINE FORMS OF VILAZODONE HYDROCHLORIDE AND VILAZODONE FREE BASE DR. REDDY'S LABORATORIES LIMITED (IN) 2019-01-03 US disclosed
US-10011590-B2 Crystalline forms of vilazodone hydrochloride and vilazodone free base DR. REDDY'S LABORATORIES LIMITED (IN) 2018-07-03 US disclosed
US-20170217939-A1 CRYSTALLINE FORMS OF VILAZODONE HYDROCHLORIDE AND VILAZODONE FREE BASE DR. REDDY'S LABORATORIES LIMITED (IN) 2017-08-03 US disclosed
US-20170183383-A1 OXYNTOMODULIN ANALOGUE SHENZHEN TURIER BIOTECH CO., LTD. (CN) 2017-06-29 US disclosed
US-20150126525-A1 CRYSTALLINE FORMS OF VILAZODONE HYDROCHLORIDE AND VILAZODONE FREE BASE REDDYS LAB LTD DR (IN) 2015-05-07 US disclosed
WO-2013168126-A1 CRYSTALLINE FORMS OF VILAZODONE HYDROCHLORIDE AND VILAZODONE FREE BASE DR.REDDYS LABORATORIES LIMITED (IN) 2013-11-14 WO disclosed
US-4113680-A Method for preparing 17 α-ester-21-halo pregnanes TAISHO PHARMACEUTICAL CO., LTD. (JP) 1978-09-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150126525-A1 CRYSTALLINE FORMS OF VILAZODONE HYDROCHLORIDE AND VILAZODONE FREE BASE VIL1, VMA21, PYGL MAPK1 3270/4885PIK3CD 2917/4885BRD4 3732/4885
US-20170217939-A1 CRYSTALLINE FORMS OF VILAZODONE HYDROCHLORIDE AND VILAZODONE FREE BASE VIL1, VMA21, PYGL MAPK1 3704/4885PIK3CD 3526/4885BRD4 4304/4885
US-20170183383-A1 OXYNTOMODULIN ANALOGUE GCGR, GLP1R, GIPR MAPK1 1834/4885PIK3CD 3614/4885BRD4 4278/4885
US-10011590-B2 Crystalline forms of vilazodone hydrochloride and vilazodone free base VIL1, VMA21, PYGL MAPK1 3704/4885PIK3CD 3526/4885BRD4 4304/4885
US-10479819-B2 Oxyntomodulin analogue GCGR, GLP1R, GIPR MAPK1 1834/4885PIK3CD 3614/4885BRD4 4278/4885
US-20190002444-A1 CRYSTALLINE FORMS OF VILAZODONE HYDROCHLORIDE AND VILAZODONE FREE BASE VIL1, VMA21, PYGL MAPK1 3704/4885PIK3CD 3526/4885BRD4 4304/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.