SCHEMBL11580971

SCHEMBL11580971

Cc1c(CCC(=O)N2CCN(C(=O)CCc3cc(C(C)(C)C)c(O)c(C)c3C)CC2)cc(C(C)(C)C)c(O)c1C

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.56
KMT2A Q03164 3/20 0.47
MEN1 O00255 2/20 0.47
CACNA1A O00555 1/20 0.40
CACNA2D1 P54289 1/20 0.40
CACNB1 Q02641 1/20 0.40
TP53 P04637 1/20 0.40
MAPT P10636 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.37
ALDH1A1 P00352 1/20 0.36
HPGD P15428 1/20 0.36
ALOX15 P16050 1/20 0.36
ALOX12 P18054 1/20 0.36
HSD17B10 Q99714 1/20 0.36
APOBEC3G Q9HC16 1/20 0.36
HSPA5 P11021 1/20 0.36
GLA P06280 1/20 0.36
RBP4 P02753 2/20 0.36
TDP1 Q9NUW8 1/20 0.36
CYP1A2 P05177 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8635233 0.81 GAA (0.67) GAAKMT2AMEN1CACNA1ACACNA2D1
SCHEMBL9192930 0.81 HSPA5 (0.41) GAAKMT2AMEN1TP53MAPT
SCHEMBL11581053 0.81 NPSR1 (0.49) GAAKMT2ATP53ALDH1A1HSPA5
SCHEMBL11750154 0.80 GAA (0.43) GAAKMT2AMEN1TP53MAPT
SCHEMBL10963429 0.80 KMT2A (0.69) GAAKMT2AMEN1CACNA1ACACNA2D1
SCHEMBL11582077 0.79 GAA (0.57) GAAKMT2AMEN1ALDH1A1HPGD
SCHEMBL9224061 0.77 VCAM1 (0.48) GAAKMT2AALDH1A1HSPA5TDP1
SCHEMBL11582433 0.77 GAA (0.48) GAAKMT2AMEN1TP53ALDH1A1
SCHEMBL11580710 0.77 GAA (0.38) GAAKMT2AALDH1A1HSPA5CYP2C9
SCHEMBL8608650 0.76 GAA (0.68) GAAKMT2AMEN1CACNA1ACACNA2D1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4101550-A STABILIZERS FOR POLYOLEFINS CIBA-GEIGY CORPORATION (US) 1978-07-18 US claimed
US-4093587-A Trisubstituted hydroxyphenylalkanoic acid ester and amide stabilized compositions CIBA-GEIGY CORPORATION (US) 1978-06-06 US claimed
US-4101550-A STABILIZERS FOR POLYOLEFINS CIBA-GEIGY CORPORATION (US) 1978-07-18 US disclosed
US-4093587-A Trisubstituted hydroxyphenylalkanoic acid ester and amide stabilized compositions CIBA-GEIGY CORPORATION (US) 1978-06-06 US disclosed
US-4049713-A STABILIZERS FOR POLYOLEFINS CIBA-GEIGY CORPORATION (US) 1977-09-20 US disclosed
US-3984460-A LIGHT AND HEAT STABILIZERS CIBA-GEIGY CORPORATION (US) 1976-10-05 US disclosed