Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Dalfampridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA1 known ✓ | Q09470 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dalfampridine SCHEMBL21084451 | 0.83 | MEN1 (0.56) | ALDH1A1MEN1KMT2AMAPTCYP2D6 | |
| Aniline SCHEMBL7517441 | 0.79 | TSHR (0.55) | ALDH1A1MEN1KMT2AMAPTCYP2D6 | |
| Dalfampridine SCHEMBL22382689 | 0.79 | ALDH1A1 (0.65) | ALDH1A1MEN1KMT2AMAPTCYP2D6 | |
| Dalfampridine SCHEMBL27592753 | 0.79 | MAPT (0.72) | ALDH1A1MEN1KMT2AMAPTCYP2D6 | |
| Dalfampridine SCHEMBL28175357 | 0.78 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2AMAPTCYP2D6 | |
| Benzidine SCHEMBL11743215 | 0.77 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2AMAPTTSHR | |
| Maleic Acid SCHEMBL9204873 | 0.76 | ALDH1A1 (0.59) | ALDH1A1MEN1KMT2AMAPTCYP2D6 | |
| Terephthalic Acid SCHEMBL27431955 | 0.76 | NAPRT (0.70) | ALDH1A1MEN1KMT2AMAPTCYP2D6 | |
| Fumaric Acid SCHEMBL4348845 | 0.76 | ALDH1A1 (0.59) | ALDH1A1MEN1KMT2AMAPTCYP2D6 | |
| Dalfampridine SCHEMBL27568416 | 0.75 | MAPT (0.87) | ALDH1A1MEN1KMT2AMAPTCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4082555-A | 3-PYRAZOLIDONE SILVER HALIDE DEVELOPING AGENT | EASTMAN KODAK COMPANY (US) | 1978-04-04 | — | — | US | disclosed |