Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 9/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 5/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11597345 | 0.85 | KDM4E (0.50) | MAPTALDH1A1GAACYP1A2CYP3A4 | |
| Iodide SCHEMBL11599406 | 0.81 | MAPT (0.62) | MAPTALDH1A1GAACYP1A2CYP3A4 | |
| Bromide SCHEMBL11598353 | 0.76 | MAPT (0.66) | MAPTALDH1A1GAACYP1A2CYP3A4 | |
| Bromide SCHEMBL11599612 | 0.74 | MAOB (0.38) | ALDH1A1GAAKDM4EMAOAMAOB | |
| Bromide SCHEMBL11598433 | 0.73 | MAPT (0.64) | MAPTALDH1A1GAACYP1A2CYP3A4 | |
| SCHEMBL21877858 | 0.67 | MAOB (0.44) | ALDH1A1GAACYP1A2CYP3A4KDM4E | |
| SCHEMBL14403381 | 0.67 | MAPT (0.75) | MAPTALDH1A1GAACYP1A2CYP3A4 | |
| Bromide SCHEMBL6120521 | 0.67 | MAPT (0.64) | MAPTALDH1A1GAACYP1A2CYP3A4 | |
| SCHEMBL10581617 | 0.67 | PDE10A (0.54) | MAPTALDH1A1GAAHPGDTDP1 | |
| SCHEMBL386377 | 0.65 | KDM4E (0.53) | ALDH1A1GAAKDM4ETDP1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4115122-A | Internal latent image silver halide emulsion containing a heterocyclic quaternary salt having a propargyl or a butyryl containing substituent | FUJI PHOTO FILM CO., LTD. (JP) | 1978-09-19 | — | — | US | claimed |
| US-4115122-A | Internal latent image silver halide emulsion containing a heterocyclic quaternary salt having a propargyl or a butyryl containing substituent | FUJI PHOTO FILM CO., LTD. (JP) | 1978-09-19 | — | — | US | disclosed |