Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.51 |
| ▸ | HTR1A | P08908 | 3/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.47 |
| ▸ | EIF4EBP1 | Q13541 | 2/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | USP19 | O94966 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 2/20 | 0.36 |
| ▸ | DHPS | P49366 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29720987 | 0.82 | GRM2 (0.50) | HTR2AHTR1ADRD2STING1EIF4EBP1 | |
| SCHEMBL23425580 | 0.81 | HTR2A (0.48) | HTR2AHTR1ADRD2STING1EIF4EBP1 | |
| SCHEMBL27136921 | 0.80 | STING1 (0.47) | HTR2AHTR1ADRD2STING1EIF4EBP1 | |
| SCHEMBL14876737 | 0.80 | HTR2A (0.48) | HTR2AHTR1ADRD2STING1EIF4EBP1 | |
| SCHEMBL13046538 | 0.77 | TNF (0.56) | KDM4ETNFMAPT | |
| SCHEMBL4249660 | 0.76 | DHPS (0.57) | HTR2AHTR1ADRD2STING1KDM4E | |
| SCHEMBL15344922 | 0.75 | BRD9 (0.44) | HTR2AHTR1ADRD2STING1GRM2 | |
| SCHEMBL29720794 | 0.75 | BRD9 (0.44) | HTR2AHTR1ADRD2STING1GRM2 | |
| SCHEMBL30782353 | 0.74 | LATS1 (0.45) | HTR2AHTR1ADRD2STING1EIF4EBP1 | |
| SCHEMBL27141591 | 0.74 | LATS1 (0.45) | HTR2AHTR1ADRD2STING1EIF4EBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459556-A1 | 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS | IRM LLC (BM) | 2012-06-06 | — | — | EP | claimed |
| WO-2011014515-A1 | 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS | IRM LLC (BM) | 2011-02-03 | — | — | WO | claimed |