SCHEMBL11601799

SCHEMBL11601799

C=CC(OC)(C(=O)c1ccccc1)c1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CES1 P23141 3/20 0.62
SRC P12931 1/20 0.45
KCNN4 O15554 1/20 0.41
TSHR P16473 4/20 0.40
AKT1 P31749 2/20 0.40
ALDH1A1 P00352 2/20 0.38
MAPK1 P28482 2/20 0.36
HIF1A Q16665 1/20 0.36
CES2 O00748 1/20 0.36
HTT P42858 1/20 0.36
TDP1 Q9NUW8 2/20 0.35
HSD17B10 Q99714 2/20 0.35
MAPT P10636 3/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
F2 P00734 1/20 0.34
LMNA P02545 1/20 0.34
KMT2A Q03164 1/20 0.34
KDM4E B2RXH2 1/20 0.34
ALOX15 P16050 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19820114 0.86 CES1 (0.66) CES1SRCKCNN4TSHRAKT1
SCHEMBL1426575 0.83 CES1 (0.49) CES1SRCKCNN4TSHRAKT1
Formaldehyde SCHEMBL28114609 0.77 CES1 (0.93) CES1SRCKCNN4TSHRALDH1A1
Formaldehyde SCHEMBL1128921 0.77 CES1 (0.93) CES1SRCKCNN4TSHRALDH1A1
SCHEMBL28324796 0.77 CES1 (0.93) CES1SRCKCNN4TSHRALDH1A1
SCHEMBL8641394 0.77 CES1 (0.53) CES1SRCKCNN4TSHRAKT1
SCHEMBL15173 0.77 CES1 (1.00) CES1SRCKCNN4TSHRALDH1A1
SCHEMBL1679763 0.77 CES1 (1.00) CES1SRCKCNN4TSHRALDH1A1
Methoxymethane SCHEMBL28719477 0.75 CES1 (0.96) CES1SRCKCNN4TSHRALDH1A1
Acrylic Acid SCHEMBL9640960 0.75 CES1 (0.73) CES1SRCKCNN4TSHRAKT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4086299-A WITH UNSATURATED CARBOXY ACID ICI AUSTRALIA LIMITED (AU) 1978-04-25 US claimed
US-4086299-A WITH UNSATURATED CARBOXY ACID ICI AUSTRALIA LIMITED (AU) 1978-04-25 US disclosed