Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.36 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.36 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | APLNR | P35414 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutarate SCHEMBL11828129 | 0.92 | SLC22A6 (0.41) | TSHRNFKB1CYP2C19LMNAMAPK1 | |
| Sebacic Acid SCHEMBL28381641 | 0.91 | TSHR (0.43) | TSHRNFKB1LMNAALDH1A1OR51E2 | |
| Sebacic Acid SCHEMBL28520265 | 0.91 | TSHR (0.43) | TSHRNFKB1LMNAALDH1A1OR51E2 | |
| Acetic Acid SCHEMBL985160 | 0.85 | TSHR (0.39) | TSHRNFKB1CYP2C19APLNRFFAR3 | |
| Succinic Acid SCHEMBL9813641 | 0.84 | KDM4E (0.36) | TSHRNFKB1CYP2C19EGLN1LMNA | |
| Tempol Hydroxylamine SCHEMBL28364622 | 0.84 | GAA (0.42) | EGLN1LMNAALKBH5SUCNR1SLC15A2 | |
| Nitrilotriacetic Acid SCHEMBL987147 | 0.83 | TSHR (0.37) | TSHRNFKB1CYP2C19LMNAKDM4E | |
| SCHEMBL76674 | 0.82 | GAA (0.39) | TSHRNFKB1CYP2C19LMNA | |
| Succinic Acid SCHEMBL2719778 | 0.82 | APEX1 (0.31) | EGLN1LMNAALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL27850794 | 0.81 | LMNA (0.33) | EGLN1LMNAALKBH5SUCNR1SLC15A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3960809-A | POLYMERS | CIBA-GEIGY CORPORATION (US) | 1976-06-01 | — | — | US | claimed |
| US-4087406-A | Metal salts of hindered piperidine carboxylic acids and stabilized compositions | CIBA-GEIGY CORPORATION (US) | 1978-05-02 | — | — | US | disclosed |
| US-4069199-A | Metal salts of hindered piperidine carboxylic acids and stabilized compositions | CIBA-GEIGY CORPORATION (US) | 1978-01-17 | — | — | US | disclosed |
| US-3960809-A | POLYMERS | CIBA-GEIGY CORPORATION (US) | 1976-06-01 | — | — | US | disclosed |
| US-3939163-A | Metal salts of hindered piperidine carboxylic acids and stabilized compositions | CIBA-GEIGY CORPORATION (US) | 1976-02-17 | — | — | US | disclosed |