Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11614676 | 0.91 | GAA (0.44) | GAARAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL11616942 | 0.90 | RAB9A (0.43) | GAARAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL11614991 | 0.89 | SMN1; SMN2 (0.42) | GAARAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL11612976 | 0.88 | RAB9A (0.44) | GAARAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL11613372 | 0.88 | RAB9A (0.44) | GAARAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL11615267 | 0.88 | SMN1; SMN2 (0.41) | GAASMN1; SMN2ALDH1A1KDM4EPTGDR2 | |
| SCHEMBL20320378 | 0.87 | HDAC3 (0.48) | GAARAB9ASMN1; SMN2LMNANPSR1 | |
| SCHEMBL11609351 | 0.85 | PTGDR2 (0.44) | GAARAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL11614081 | 0.84 | RAB9A (0.43) | GAARAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL11618584 | 0.83 | RAB9A (0.42) | GAARAB9ASMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4117145-A | DIURETIC, HYPOTENSIVE, ANTITHROMBOTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-26 | — | — | US | disclosed |
| US-4117143-A | USED AS ANTITHROMBOTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-26 | — | — | US | disclosed |
| US-4113957-A | DIURETIC, SALURETIC, HYPOTENSIVE, ANTITHROMBOTIC | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-12 | — | — | US | disclosed |