Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.76 |
| ▸ | NAMPT | P43490 | 16/20 | 0.75 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.69 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | MMP13 | P45452 | 1/20 | 0.67 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13603748 | 0.92 | HTT (0.76) | HTTNAMPTROCK2ROCK1LMNA | |
| SCHEMBL16990619 | 0.87 | HTT (0.64) | HTTNAMPTROCK2ROCK1 | |
| SCHEMBL11616834 | 0.87 | HTT (1.00) | HTTNAMPTROCK2ROCK1SMN1; SMN2 | |
| SCHEMBL28111895 | 0.86 | NAMPT (1.00) | HTTNAMPTLMNASMN1; SMN2 | |
| SCHEMBL13603754 | 0.85 | NAMPT (0.80) | HTTNAMPTLMNASMN1; SMN2 | |
| SCHEMBL13603751 | 0.85 | NAMPT (0.65) | HTTNAMPTROCK2ROCK1LMNA | |
| SCHEMBL15574780 | 0.84 | KMT2A (0.60) | HTTNAMPTROCK2ROCK1 | |
| SCHEMBL15574772 | 0.84 | NAMPT (0.78) | HTTNAMPTCYP3A4MAPK14 | |
| SCHEMBL15573250 | 0.84 | NAMPT (0.67) | HTTNAMPTCYP3A4MAPK14 | |
| SCHEMBL15573354 | 0.84 | SMN1; SMN2 (0.70) | HTTNAMPTCYP3A4MMP13MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4088766-A | PRODUCTION OF PROSTAGLANDINS IN MAMMALS | THE UPJOHN COMPANY (US) | 1978-05-09 | — | — | US | disclosed |
| US-4001256-A | PROSTAGLANDIN PRODUCTION IN MAMMALS | THE UPJOHN COMPANY (US) | 1977-01-04 | — | — | US | disclosed |