Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 11/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
| ▸ | HTT | P42858 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL164075 | 0.89 | NAMPT (0.84) | NAMPTCYP2C9 | |
| SCHEMBL13603754 | 0.89 | NAMPT (0.80) | NAMPTKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL11614852 | 0.88 | SMN1; SMN2 (0.81) | NAMPTLMNAHTTKMT2AMEN1 | |
| Ammonia Solution, Strong SCHEMBL29131270 | 0.87 | SMN1; SMN2 (0.79) | NAMPTLMNAHTTKMT2AMEN1 | |
| SCHEMBL15583798 | 0.87 | NAMPT (0.76) | NAMPTKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL20379359 | 0.86 | NAMPT (0.85) | NAMPTKDM4EKMT2AMEN1POLB | |
| SCHEMBL11615046 | 0.86 | HTT (0.76) | NAMPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL166487 | 0.85 | MAPT (1.00) | NAMPTKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL12334453 | 0.85 | NAMPT (0.73) | NAMPTKMT2AMEN1CYP2C9POLB | |
| SCHEMBL12335465 | 0.85 | NAMPT (0.75) | NAMPTKMT2AMEN1CYP2C9POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103270023-B | 4- { [ (pyridin-3-yl-methyl) aminocarbonyl ] amino } benzene-sulfone derivatives as NAMPT inhibitors for the treatment of diseases such as cancer | 福马TM有限责任公司 | 2016-11-02 | — | — | CN | claimed |