Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 9/20 | 0.59 |
| ▸ | SCNN1A | P37088 | 9/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | GLA | P06280 | 5/20 | 0.57 |
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | THPO | P40225 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 2/20 | 0.56 |
| ▸ | GMNN | O75496 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzamil SCHEMBL5433990 | 0.94 | PLAU (0.63) | PLAUSCNN1AALDH1A1KDM4EGLA | |
| Benzamil SCHEMBL4242779 | 0.94 | PLAU (0.63) | PLAUSCNN1AALDH1A1KDM4EGLA | |
| Benzamil SCHEMBL412783 | 0.94 | PLAU (0.63) | PLAUSCNN1AALDH1A1KDM4EGLA | |
| Benzamil SCHEMBL9464171 | 0.93 | PLAU (0.64) | PLAUSCNN1AALDH1A1KDM4EGLA | |
| SCHEMBL10028719 | 0.82 | SCNN1A (0.61) | PLAUSCNN1AALDH1A1KDM4EGLA | |
| Hydrochloric Acid SCHEMBL11618253 | 0.81 | PLAU (0.60) | PLAUSCNN1AALDH1A1KDM4EGLA | |
| SCHEMBL11618564 | 0.81 | PLAU (0.58) | PLAUSCNN1AALDH1A1KDM4EGLA | |
| SCHEMBL5065784 | 0.81 | KCNH2 (0.51) | PLAUSCNN1AALDH1A1KDM4EGLA | |
| 3',4' Dichlorobenzamil SCHEMBL14504158 | 0.80 | HSD17B10 (0.60) | PLAUSCNN1AALDH1A1KDM4EGLA | |
| SCHEMBL5014171 | 0.80 | SCNN1A (0.52) | PLAUSCNN1AALDH1A1KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4085211-A | DIURETICS, NATRIURETICS | MERCK & CO., INC. (US) | 1978-04-18 | — | — | US | disclosed |