Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.45 |
| ▸ | LITAF | Q99732 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 7/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 7/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1161666 | 0.81 | ELANE (0.43) | KDM4EHSD17B10KCNH2HRH3HSP90AB1 | |
| SCHEMBL1161764 | 0.80 | NPC1 (0.45) | KDM4EKCNH2HRH3HSP90AB1PARP1 | |
| SCHEMBL1161349 | 0.80 | TRPV4 (0.41) | KDM4EGAAHTTHSD17B10KCNH2 | |
| SCHEMBL7571452 | 0.80 | HRH3 (0.50) | TNFLITAFKDM4EALDH1A1HPGD | |
| SCHEMBL1161747 | 0.78 | ELANE (0.46) | KDM4EALDH1A1HPGDKCNH2HRH3 | |
| SCHEMBL13833569 | 0.70 | KDM4E (0.42) | KDM4EHSD17B10KCNH2HRH3HSP90AB1 | |
| SCHEMBL28676361 | 0.70 | SMN1; SMN2 (0.62) | TNFLITAFKDM4EALDH1A1HPGD | |
| SCHEMBL11284009 | 0.70 | KCNH2 (0.45) | TNFLITAFKDM4EALDH1A1GLA | |
| SCHEMBL1161533 | 0.69 | CYP3A4 (0.55) | KDM4EALDH1A1GLAKCNH2HRH3 | |
| SCHEMBL1161641 | 0.69 | ALPG (0.46) | KDM4EALDH1A1HPGDGLAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011012622-A1 | BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF GLYTL MEDIATED DISORDERS | GLAXO GROUP LIMITED (GB) | 2011-02-03 | — | — | WO | disclosed |
| WO-2011012622-A1 | BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF GLYTL MEDIATED DISORDERS | GLAXO GROUP LIMITED (GB) | 2011-02-03 | — | — | WO | disclosed |