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TRPV4

Transient receptor potential cation channel subfamily V member 4 · Q9HBA0 · TRPV4 on Sugi Atlas →

38,766 patent compounds predicted against TRPV4, 18,347 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL474656 SCHEMBL474656 0.67 16/20
SCHEMBL474848 SCHEMBL474848 0.81 15/20
SCHEMBL474671 SCHEMBL474671 0.77 15/20
SCHEMBL474596 SCHEMBL474596 0.78 14/20
SCHEMBL266426 SCHEMBL266426 0.64 14/20
SCHEMBL330102 SCHEMBL330102 0.45 14/20
SCHEMBL474604 SCHEMBL474604 0.78 13/20
SCHEMBL461735 SCHEMBL461735 0.42 13/20
SCHEMBL474789 SCHEMBL474789 1.00 12/20
SCHEMBL474659 SCHEMBL474659 0.98 12/20
SCHEMBL612806 SCHEMBL612806 0.77 12/20
SCHEMBL474519 SCHEMBL474519 0.74 12/20
SCHEMBL612877 SCHEMBL612877 0.71 12/20
SCHEMBL475324 SCHEMBL475324 0.71 12/20
SCHEMBL476194 SCHEMBL476194 0.79 11/20
SCHEMBL474905 SCHEMBL474905 0.78 11/20
SCHEMBL474733 SCHEMBL474733 0.77 11/20
SCHEMBL609319 SCHEMBL609319 0.72 11/20
SCHEMBL611669 SCHEMBL611669 0.72 11/20
SCHEMBL608603 SCHEMBL608603 0.70 11/20

Clinical trials — most relevant to TRPV4 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
TRPV Expression in Subjects With Sensitive Skin PHASE4UNKNOWN
Mechanisms of Capsaicin Treatment in Idiopathic Rhinitis Patients and Controls PHASE4COMPLETED
The Re-Prosper HF Study PHASE2/PHASE3COMPLETED
Botulinum Toxin Injections for Oral Neuropathic Pain PHASE3COMPLETED
Study Designed to Evaluate Safety and Efficacy of 1% Topical Formulation of KM-001 on Type 1 Punctate Palmoplantar Keratoderma or Pachyonychia Congenita Diseases PHASE1COMPLETED
Assessment of KM-001 - Safety, Tolerability, and Efficacy in Patients With PPPK1 or PC PHASE1COMPLETED
Do Acid Sensing Ion Channels Contribute to Heartburn? PHASE1COMPLETED
Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8 EARLY_PHASE1COMPLETED
Mechanisms of Human Heat Perception - Involvement of TRPA1, TRPV1 and TRPM3 EARLY_PHASE1COMPLETED
Menthol Stimulation of Brown Adipose Tissue in Humans: Aim 1 EARLY_PHASE1RECRUITING
The Natural History of TRPV4 Neuropathy nanRECRUITING
Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin nanENROLLING_BY_INVITATION
Identification of TRP Channels as New Potential Therapeutic Targets in Primary and Secondary Raynaud's Phenomenon. nanCOMPLETED
Dissecting the Heterogeneity of Oral Cancer Pain nanUNKNOWN
Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain nanRECRUITING
Relationship Between Polymorphisms of TRPV1 and KCC2 Gene in Children With Febrile Seizures nanCOMPLETED
Neurogenic Mechanisms in Burning Mouth Syndrome nanCOMPLETED
Qutenza 8% Capsaicin Topical System for the Treatment of Neuropathic Axial Lower Back Pain and Lumbosacral Radiculopathy nanENROLLING_BY_INVITATION
Nutrition for Migraine Prevention nanCOMPLETED
Factors Affecting Salt Intake in Young Adults nanUNKNOWN
A Study on the Mechanism of Cough Hypersensitivity nanUNKNOWN
Expressions of TRPV1 in Airway of Asthmatics nanWITHDRAWN
Effect of Boswellia Serrata on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers nanRECRUITING
An Investigation Into the Mechanism of Inhalation Cough Challenge nanCOMPLETED
Detection of Cav1 Calcium Channels in Inflammatory Cells of Asthmatic Children nanCOMPLETED
Efficacy and Safety of a Novel Monopolar Radiofrequency Device for Mid and Lower Face Rejuvenation nanCOMPLETED
Effects of Photobiomodulation on the Innate Immune System of Neonates and Infants With Bronchiolitis nanUNKNOWN
Precision Medicine for Sng/Pain Control nanCOMPLETED
Characterization and Functionality of Calcium Channels Cav1.4 of Th17 Lymphocytes in Human With Psoriasis nanCOMPLETED
Microneurographic Assessment of Peripheral Nerves in Healthy Volunteers and Individuals With Sensory Dysfunction Caused by Inherited Mutations in the PIEZO2 Gene nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a TRPV4 binder may also engage these)

ProteinNameSimilarity
Q9ERZ8 — 1.000 Q9ERZ8 →
Q9EPK8 — 1.000 Q9EPK8 →
A0A1D5PXA5 — 1.000 A0A1D5PXA5 →
Q704Y3 — 1.000 Q704Y3 →
TRPV1 Transient receptor potential cation channel subfamily V member 1 1.000 landscape →
Q6R5A3 — 1.000 Q6R5A3 →
Q6RX08 — 1.000 Q6RX08 →
Q8K424 — 0.996 Q8K424 →
Q697L1 — 0.996 Q697L1 →
O35433 — 0.996 O35433 →
Q9R186 — 0.995 Q9R186 →
TRPV3 Transient receptor potential cation channel subfamily V member 3 0.995 landscape →
P19334 — 0.994 P19334 →
Q9QUQ5 — 0.992 Q9QUQ5 →
P48994 — 0.992 P48994 →
Q9MYV9 — 0.992 Q9MYV9 →
Q9XSM3 — 0.991 Q9XSM3 →
P34586 — 0.991 P34586 →
P79100 — 0.991 P79100 →
P69744 — 0.991 P69744 →
Q91WD2 — 0.990 Q91WD2 →
Q5ICL9 — 0.990 Q5ICL9 →
Q9QX29 — 0.990 Q9QX29 →
Q61056 — 0.990 Q61056 →
Q6ZPS6 — 0.990 Q6ZPS6 →
Q9JIP0 — 0.990 Q9JIP0 →
O35119 — 0.989 O35119 →
TRPC5 Short transient receptor potential channel 5 0.989 landscape →
TRPC4 Short transient receptor potential channel 4 0.989 landscape →
O62852 — 0.989 O62852 →