Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 2/20 | 0.44 |
| ▸ | IDO2 | Q6ZQW0 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | TNKS | O95271 | 2/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | PARG | Q86W56 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1161773 | 0.88 | HDAC6 (0.42) | HDAC6CASRL3MBTL1KCNH2HRH3 | |
| SCHEMBL1161132 | 0.85 | HDAC6 (0.45) | TDO2IDO2IDO1HDAC6CASR | |
| SCHEMBL1161602 | 0.83 | L3MBTL1 (0.44) | TDO2IDO2IDO1HDAC6CASR | |
| SCHEMBL9919072 | 0.78 | POLB (0.55) | TDO2IDO2IDO1CASRL3MBTL1 | |
| SCHEMBL31542053 | 0.73 | HDAC6 (0.56) | HDAC6KCNH2 | |
| SCHEMBL5741522 | 0.72 | USP2 (0.48) | HDAC6CASP3PARG | |
| SCHEMBL3820085 | 0.72 | USP2 (0.47) | HDAC6CASP3 | |
| SCHEMBL1161767 | 0.71 | L3MBTL1 (0.44) | HDAC6CASRL3MBTL1KCNH2HRH3 | |
| SCHEMBL16854205 | 0.70 | HDAC1 (0.55) | TDO2IDO2IDO1HDAC6L3MBTL1 | |
| SCHEMBL1161308 | 0.70 | TRPV1 (0.41) | HDAC6L3MBTL1POLBCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011012622-A1 | BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF GLYTL MEDIATED DISORDERS | GLAXO GROUP LIMITED (GB) | 2011-02-03 | — | — | WO | disclosed |
| WO-2011012622-A1 | BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF GLYTL MEDIATED DISORDERS | GLAXO GROUP LIMITED (GB) | 2011-02-03 | — | — | WO | disclosed |