Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.44 |
| ▸ | CDC25B | P30305 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28493002 | 0.92 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1CYP3A4HPGDAKR1C3 | |
| SCHEMBL5226978 | 0.83 | POLB (0.50) | SMN1; SMN2ALDH1A1CYP3A4HPGDAKR1C3 | |
| SCHEMBL1651653 | 0.81 | KDM4E (0.49) | SMN1; SMN2ALDH1A1CYP3A4HPGDMAPK1 | |
| SCHEMBL7827443 | 0.81 | LCK (0.52) | SMN1; SMN2ALDH1A1CYP3A4HPGDAKR1C3 | |
| SCHEMBL31125235 | 0.81 | LCK (0.52) | SMN1; SMN2ALDH1A1CYP3A4HPGDAKR1C3 | |
| SCHEMBL16693774 | 0.79 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1HPGDCDC25BPOLB | |
| SCHEMBL15304947 | 0.78 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1CYP3A4HPGDAKR1C3 | |
| SCHEMBL27468745 | 0.78 | TPMT (0.48) | SMN1; SMN2ALDH1A1AKR1C3AKR1C2KDM4E | |
| SCHEMBL3037245 | 0.77 | ALDH1A1 (0.65) | SMN1; SMN2ALDH1A1CYP3A4HPGDMAPK1 | |
| SCHEMBL4128750 | 0.77 | ALDH1A1 (0.65) | SMN1; SMN2ALDH1A1CYP3A4HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4127666-A | ANTIEMETIC | UNIVERSITE D'ORLEANS (FR) | 1978-11-28 | — | — | US | disclosed |