2'-Beta-Methyl-Guanosine

2'-Beta-Methyl-Guanosine

SCHEMBL116165

COC[C@H]1O[C@@H](n2cnc3c(=O)[nH]c(N)nc32)[C@H](O)[C@@H]1O

nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HINT1 P49773 6/20 0.75
NT5E P21589 1/20 0.72
GSK3A P49840 2/20 0.67
RPS6KA3 P51812 2/20 0.67
MAPK14 Q16539 2/20 0.67
TGM2 P21980 1/20 0.66
ADORA3 P0DMS8 1/20 0.65
PNP P00491 1/20 0.64
IMPDH2 P12268 1/20 0.63
IMPDH1 P20839 1/20 0.63
FUT5 Q11128 1/20 0.61
KRAS P01116 5/20 0.60
HPGD P15428 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2'-Beta-Methyl-Guanosine SCHEMBL11965261 1.00 HINT1 (0.75) HINT1NT5EGSK3ARPS6KA3MAPK14
2'-Beta-Methyl-Guanosine SCHEMBL383785 1.00 HINT1 (0.75) HINT1NT5EGSK3ARPS6KA3MAPK14
2'-Beta-Methyl-Guanosine SCHEMBL14178410 1.00 HINT1 (0.75) HINT1NT5EGSK3ARPS6KA3MAPK14
2'-Beta-Methyl-Guanosine SCHEMBL15338533 1.00 HINT1 (0.75) HINT1NT5EGSK3ARPS6KA3MAPK14
2'-Beta-Methyl-Guanosine SCHEMBL5972612 0.99 HINT1 (0.73) HINT1NT5EGSK3ARPS6KA3MAPK14
SCHEMBL4369589 0.92 HINT1 (0.64) HINT1NT5EGSK3ARPS6KA3MAPK14
SCHEMBL4377553 0.92 HINT1 (0.64) HINT1NT5EGSK3ARPS6KA3MAPK14
SCHEMBL22475009 0.92 HINT1 (0.64) HINT1NT5EGSK3ARPS6KA3MAPK14
SCHEMBL14782966 0.92 HINT1 (0.72) HINT1NT5EGSK3ARPS6KA3MAPK14
SCHEMBL2533738 0.91 HINT1 (0.69) HINT1NT5EGSK3ARPS6KA3MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3769 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12460204-B2 Artificial nucleic acid molecules for improved protein or peptide expression CureVac SE (DE) 2025-11-04 US claimed
US-20250263678-A1 COMPOSITIONS AND METHODS FOR DELIVERY OF RNA REJUVENATION TECHNOLOGIES, INC. (US) 2025-08-21 US claimed
WO-2025128901-A1 CIRCULAR RNA MOLECULES ARCTURUS THERAPEUTICS, INC. (US) 2025-06-19 WO claimed
CN-120064427-A Method and analysis system for detecting brain nucleic acid hydrolysate spatial distribution based on mass spectrum imaging 北京脑科学与类脑研究所 2025-05-30 CN claimed
US-20250152737-A1 LIPID NANOPARTICLES COMPRISING VENEZUELAN EQUINE ENCEPHALITIS (VEE) REPLICON AND USES THEREOF STRAND THERAPEUTICS INC. (US) 2025-05-15 US claimed
CN-119907691-A Carbohydrate-oligonucleotide conjugates, pharmaceutical compositions and therapeutic uses 厦门甘宝利生物医药有限公司 2025-04-29 CN claimed
WO-2025081087-A1 METHODS FOR CENTRAL NERVOUS SYSTEM NUCLEIC ACID DELIVERY ARCTURUS THERAPEUTICS, INC. (US) 2025-04-17 WO claimed
CN-119789859-A Treatment of non-alcoholic fatty liver disease 箭头药业股份有限公司 2025-04-08 CN claimed
CN-119614577-A Anti-CD 3 nucleic acid aptamer for cell targeting and labeling 艾夏卡法国有限公司 2025-03-14 CN claimed
CN-118541485-A RNAi agents for inhibiting expression of matrix metalloproteinase 7 (MMP 7), compositions thereof and methods of use 箭头药业股份有限公司 2024-08-23 CN claimed
EP-0948256-A4 INDUCTION OF VIRAL MUTATION BY INCORPORATION OF MISCODING RIBONUCLEOSIDE ANALOGS INTO VIRAL RNA UNIV WASHINGTON (US) 2007-10-24 EP claimed
US-6887707-B2 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA UNIVERSITY OF WASHINGTON (US) 2005-05-03 US claimed
EP-1485395-A2 NUCLEOTIDE MIMICS AND THEIR PRODRUGS Biota, Inc. (US) 2004-12-15 EP claimed
WO-2003072757-A9 NUCLEOTIDE MIMICS AND THEIR PRODRUGS BIOTA INC (US) 2004-10-21 WO claimed
WO-2003072757-A2 NUCLEOTIDE MIMICS AND THEIR PRODRUGS BIOTA, INC. (US) 2003-09-04 WO claimed
US-20030119764-A1 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2003-06-26 US claimed
EP-0948256-A1 INDUCTION OF VIRAL MUTATION BY INCORPORATION OF MISCODING RIBONUCLEOSIDE ANALOGS INTO VIRAL RNA THE UNIVERSITY OF WASHINGTON (US) 1999-10-13 EP claimed
WO-1998018324-A1 INDUCTION OF VIRAL MUTATION BY INCORPORATION OF MISCODING RIBONUCLEOSIDE ANALOGS INTO VIRAL RNA THE UNIVERSITY OF WASHINGTON (US) 1998-05-07 WO claimed
US-5075225-A PROCESS FOR THE ENZYMATIC SYNTHESIS OF NUCLEOSIDES THE TEXAS A&M UNIVERSITY SYSTEM (US) 1991-12-24 US claimed
EP-0391592-A1 Process for the enzymatic synthesis of nucleosides THE TEXAS A & M UNIVERSITY SYSTEM (US) 1990-10-10 EP claimed