HINT1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL439016	0.78	9/20
SCHEMBL784432	0.75	9/20
SCHEMBL1533274	0.73	9/20
SCHEMBL1919146	0.58	9/20
SCHEMBL2108884	0.48	9/20
SCHEMBL2116029	0.47	9/20
SCHEMBL2674769	0.72	8/20
SCHEMBL2675383	0.72	8/20
SCHEMBL2675390	0.71	8/20
SCHEMBL1506297	0.67	8/20
SCHEMBL2680046	0.61	8/20
SCHEMBL313746	0.51	8/20
SCHEMBL313747	0.51	8/20
SCHEMBL217117	0.80	7/20
SCHEMBL1611244	0.77	7/20
SCHEMBL2994004	0.72	7/20
SCHEMBL1274196	0.65	7/20
SCHEMBL1506367	0.65	7/20
SCHEMBL1164486	0.64	7/20
SCHEMBL2337631	0.61	7/20

Clinical trials — most relevant to HINT1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Pharmacogenomic Evaluation of Antihypertensive Responses	PHASE4	COMPLETED
Applying Proton Pump Inhibitor to Prevent and Treat Acute Fluctuating Hearing Loss in Patients With SLC26A4 Mutation	PHASE2/PHASE3	UNKNOWN
Homocystinuria: Treatment With N-Acetylcysteine	PHASE2	COMPLETED
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED
Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan	nan	ENROLLING_BY_INVITATION
Cytomegalovirus Testing and Intervention Protocol for Newborn Nursery and Newborn Intensive Care Unit	nan	COMPLETED
Family Blood Pressure Program - GenNet Network	nan	COMPLETED
A Study on Risk Mutations of Vulnerability Genes of Schizophrenia	nan	UNKNOWN
Family Blood Pressure Program - HyperGEN	nan	COMPLETED
Hypophosphatemic Rickets in Norway	nan	UNKNOWN
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients.	nan	COMPLETED
Genetics of Middle Ear Disease	nan	COMPLETED
Exome Analysis in Hearing Impaired Patients	nan	UNKNOWN
United States Hypophosphatasia Molecular Research Center	nan	COMPLETED
Family Blood Pressure Program - SAPPHIRe Network	nan	COMPLETED
Genetic Studies in Patients and Families With Infantile Spasms	nan	COMPLETED
Study of Resting and Exercising Body Functioning in Freeman-Sheldon Syndrome and Related Conditions	nan	WITHDRAWN
Genetic Feature of Congenital Hearing Loss in Chinese Population	nan	NOT_YET_RECRUITING
Combined Electric and Acoustic Hearing (EAS) in Children and Adults	nan	RECRUITING
Stress and Treatment Response in Puerto Rican Children With Asthma	nan	COMPLETED
UW Undiagnosed Genetic Diseases Program	nan	RECRUITING
Identification of New Genes Implicated in Rare Neurosensory Diseases by Whole Exome Sequencing	nan	UNKNOWN
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart	nan	UNKNOWN
A Prospective Study of Molecular Detection of Salvageable Early Recurrent Nasopharyngeal Carcinoma After Radiotherapy	nan	COMPLETED
Genetic Testing in Detection of Late-Onset Hearing Loss	nan	COMPLETED
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
Genetic Markers of Coronary Heart Disease in Type 2 Diabetes	nan	COMPLETED
Single Gene Polymorphisms Associated With Molar-Incisor Hypomineralization	nan	UNKNOWN
Family Blood Pressure Program - GENOA	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a HINT1 binder may also engage these)

Protein	Name	Similarity
Q5RF69	—	1.000	Q5RF69 →
P80912	—	1.000	P80912 →
P62958	—	1.000	P62958 →
P70349	—	1.000	P70349 →
P62959	—	0.999	P62959 →
P53795	—	0.994	P53795 →
P42855	—	0.988	P42855 →
Q23921	—	0.988	Q23921 →
P42856	—	0.987	P42856 →
P44956	—	0.981	P44956 →
P26724	—	0.979	P26724 →
Q9Z863	—	0.979	Q9Z863 →
Q8GUN2	—	0.978	Q8GUN2 →
C4LYI2	—	0.977	C4LYI2 →
Q9PK09	—	0.974	Q9PK09 →
O66536	—	0.973	O66536 →
O07817	—	0.973	O07817 →
P64382	—	0.973	P64382 →
O07513	—	0.972	O07513 →
O94586	—	0.971	O94586 →
P64383	—	0.970	P64383 →
P0ACE9	—	0.969	P0ACE9 →
Q9JIX3	—	0.967	Q9JIX3 →
P47378	—	0.967	P47378 →
Q9ZDL1	—	0.965	Q9ZDL1 →
O76463	—	0.962	O76463 →
Q04344	—	0.962	Q04344 →
Q9FK51	—	0.961	Q9FK51 →
Q63ZT8	—	0.960	Q63ZT8 →
Q6GNL7	—	0.960	Q6GNL7 →