Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10492558 | 0.95 | HPGD (0.50) | HPGDRAB9ANPC1MAPK1HTT | |
| SCHEMBL7895255 | 0.93 | PTGS2 (0.56) | HPGDRAB9ANPC1MAPK1HTT | |
| SCHEMBL15804002 | 0.91 | PTGS2 (0.57) | HPGDRAB9APTGS2CYP3A4GPR84 | |
| SCHEMBL9168375 | 0.91 | PTGS2 (0.57) | HPGDRAB9APTGS2CYP3A4GPR84 | |
| SCHEMBL9170666 | 0.91 | PTGS2 (0.57) | HPGDRAB9APTGS2CYP3A4GPR84 | |
| SCHEMBL28579097 | 0.88 | PTGS2 (0.56) | HPGDRAB9ANPC1MAPK1HTT | |
| SCHEMBL840688 | 0.87 | PTGS2 (0.50) | HPGDRAB9ANPC1MAPK1HTT | |
| SCHEMBL2002090 | 0.87 | HPGD (0.61) | HPGDRAB9ANPC1MAPK1HTT | |
| SCHEMBL6681772 | 0.86 | PTGS2 (0.57) | HPGDRAB9APTGS2CYP3A4GPR84 | |
| SCHEMBL10492707 | 0.86 | PTGS2 (0.57) | HPGDRAB9APTGS2CYP3A4GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4112100-A | INCREASING THE ENDOGENOUS PRODUCTION OF PROSTAGLANDINS | THE UPJOHN COMPANY (US) | 1978-09-05 | — | — | US | disclosed |
| US-4088766-A | PRODUCTION OF PROSTAGLANDINS IN MAMMALS | THE UPJOHN COMPANY (US) | 1978-05-09 | — | — | US | disclosed |
| US-4001256-A | PROSTAGLANDIN PRODUCTION IN MAMMALS | THE UPJOHN COMPANY (US) | 1977-01-04 | — | — | US | disclosed |