Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 9/20 | 0.39 |
| ▸ | HTR2B | P41595 | 8/20 | 0.39 |
| ▸ | HTR2A | P28223 | 7/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL644545 | 0.94 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3ADRB1SIGMAR1 | |
| Bromide SCHEMBL27797303 | 0.92 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3ADRB1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL5793498 | 0.92 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3ADRB1SIGMAR1 | |
| SCHEMBL16731889 | 0.79 | SLC6A4 (0.47) | SLC6A2SLC6A4SLC6A3ADRB1OPRD1 | |
| SCHEMBL27865382 | 0.79 | OPRM1 (0.46) | SLC6A2SLC6A4SLC6A3ADRB1HTR2C | |
| SCHEMBL21360310 | 0.79 | SLC6A4 (0.47) | SLC6A2SLC6A4SLC6A3ADRB1OPRD1 | |
| SCHEMBL5506036 | 0.79 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3ADRB1SIGMAR1 | |
| SCHEMBL2721007 | 0.79 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3ADRB1SIGMAR1 | |
| SCHEMBL14896054 | 0.78 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3ADRB1SIGMAR1 | |
| SCHEMBL15974677 | 0.78 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3ADRB1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4067982-A | LOWERING BLOOD PRESSURE, ANALGESIC, SEDATIVE, ANTIHISTAMINE | Gulden, Byk (DT) | 1978-01-10 | — | — | US | disclosed |
| US-3957786-A | HYPOTENSIVE AGENTS | BYK GULDEN (DT) | 1976-05-18 | — | — | US | disclosed |