Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.68 |
| ▸ | NOTUM | Q6P988 | 7/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.57 |
| ▸ | PDE4A | P27815 | 3/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13070907 | 0.86 | NOTUM (0.54) | KDRNOTUMCYP1A2PDE4APDE4B | |
| SCHEMBL1769907 | 0.84 | KDR (0.50) | KDRNOTUMCYP1A2PDE4APDE4B | |
| SCHEMBL12649071 | 0.83 | KDR (0.50) | KDRNOTUMCYP1A2PDE4APDE4B | |
| Potassium SCHEMBL11736530 | 0.83 | LMNA (0.54) | KDRNOTUMCYP1A2PDE4APDE4B | |
| SCHEMBL1769717 | 0.82 | NOTUM (0.57) | KDRNOTUMCYP1A2PDE4APDE4B | |
| SCHEMBL11622439 | 0.82 | KDR (0.49) | KDRNOTUMCYP1A2PDE4APDE4B | |
| SCHEMBL13071034 | 0.82 | KDR (0.49) | KDRNOTUMCYP1A2PDE4APDE4B | |
| SCHEMBL12648982 | 0.82 | KDR (0.52) | KDRNOTUMCYP1A2PDE4APDE4B | |
| SCHEMBL12595788 | 0.82 | NOTUM (0.57) | KDRNOTUMCYP1A2PDE4APDE4B | |
| SCHEMBL3020961 | 0.81 | LMNA (0.56) | KDRNOTUMCYP1A2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4112095-A | 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1978-09-05 | — | — | US | disclosed |