Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.60 |
| ▸ | MET | P08581 | 1/20 | 0.60 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.60 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.60 |
| ▸ | AXL | P30530 | 1/20 | 0.60 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.43 |
| ▸ | AKT2 | P31751 | 3/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 4/20 | 0.37 |
| ▸ | NSD2 | O96028 | 3/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | YES1 | P07947 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1162294 | 1.00 | FGFR1 (0.60) | FGFR1METFGFR2FGFR3AXL | |
| Hydrochloric Acid SCHEMBL260791 | 0.99 | FGFR1 (0.59) | FGFR1METFGFR2FGFR3AXL | |
| Hydrochloric Acid SCHEMBL260792 | 0.99 | FGFR1 (0.59) | FGFR1METFGFR2FGFR3AXL | |
| SCHEMBL1225437 | 0.99 | FGFR1 (0.61) | FGFR1METFGFR2FGFR3AXL | |
| SCHEMBL1225440 | 0.99 | FGFR1 (0.61) | FGFR1METFGFR2FGFR3AXL | |
| Hydrochloric Acid SCHEMBL260365 | 0.98 | FGFR1 (0.60) | FGFR1METFGFR2FGFR3AXL | |
| Hydrochloric Acid SCHEMBL260366 | 0.98 | FGFR1 (0.60) | FGFR1METFGFR2FGFR3AXL | |
| SCHEMBL260188 | 0.93 | FGFR1 (0.69) | FGFR1METFGFR2FGFR3AXL | |
| SCHEMBL260189 | 0.93 | FGFR1 (0.69) | FGFR1METFGFR2FGFR3AXL | |
| Hydrochloric Acid SCHEMBL260953 | 0.92 | FGFR1 (0.68) | FGFR1METFGFR2FGFR3AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2281822-B1 | New dihydroindolone derivatives, method of preparing same and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2013-01-16 | — | — | EP | disclosed |
| WO-2011015728-A1 | NOVEL DIHYDROINDOLONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2011-02-10 | — | — | WO | disclosed |
| EP-2281822-A1 | New dihydroindolone derivatives, method of preparing same and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2011-02-09 | — | — | EP | disclosed |