Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 7/20 | 0.64 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | STS | P08842 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | HRH2 | P25021 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11622855 | 0.95 | HSD17B3 (0.62) | HSD17B3HTR7HPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL1356013 | 0.95 | HSD17B3 (0.70) | HSD17B3HTR7KDM4EALDH1A1POLB | |
| SCHEMBL7905138 | 0.93 | HSD17B3 (0.71) | HSD17B3HTR7L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL10832302 | 0.93 | HSD17B3 (0.71) | HSD17B3HTR7L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL31186967 | 0.93 | HSD17B3 (0.71) | HSD17B3HTR7L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL1356249 | 0.89 | HSD17B3 (0.69) | HSD17B3HTR7HPGDL3MBTL1ALDH1A1 | |
| SCHEMBL19757465 | 0.88 | HSD17B3 (0.65) | HSD17B3HTR7KDM4EALDH1A1POLB | |
| SCHEMBL11621590 | 0.87 | SMN1; SMN2 (0.70) | HSD17B3HPGDSMN1; SMN2L3MBTL1MMP2 | |
| SCHEMBL19757432 | 0.85 | HSD17B3 (0.61) | HSD17B3HTR7STSS1PR5 | |
| SCHEMBL28750319 | 0.85 | MMP1 (0.60) | HSD17B3HTR7L3MBTL1STSMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4125612-A | N-1-(p-Biphenylalkyl)piperazines and their use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1978-11-14 | — | — | US | disclosed |