Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 4/20 | 0.51 |
| ▸ | PHGDH | O43175 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 2/20 | 0.46 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.45 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.45 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11624932 | 0.85 | KMT2A (0.48) | RORCKMT2AHRH3CYP3A4CYP3A5 | |
| SCHEMBL11622595 | 0.85 | KCNK3 (0.51) | CACNA2D1CACNA1BCACNB1CACNA1CKMT2A | |
| SCHEMBL11625127 | 0.82 | KMT2A (0.48) | KMT2AHRH3MCHR1CYP3A4CYP3A5 | |
| SCHEMBL11623725 | 0.82 | CYP3A4 (0.53) | KMT2AHRH3MCHR1CYP3A4CYP3A5 | |
| SCHEMBL11620917 | 0.80 | OGA (0.46) | KMT2AHRH3DPP4DPP8DPP7 | |
| SCHEMBL20883809 | 0.79 | KMT2A (0.54) | KMT2ACYP3A4CYP3A5ALDH1A1 | |
| SCHEMBL11623680 | 0.78 | OGA (0.46) | KMT2AHRH3CYP3A4CYP3A5ALDH1A1 | |
| SCHEMBL22542160 | 0.78 | KMT2A (0.53) | CACNA2D1CACNA1BCACNB1CACNA1CKMT2A | |
| SCHEMBL11627222 | 0.77 | CHRM2 (0.54) | TEAD1PHGDHRORCMCHR1ALDH1A1 | |
| SCHEMBL2392112 | 0.77 | KMT2A (0.51) | KMT2AMCHR1CYP3A4CYP3A5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4125612-A | N-1-(p-Biphenylalkyl)piperazines and their use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1978-11-14 | — | — | US | disclosed |