Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Leucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.51 |
| ▸ | SLC1A2 | P43004 | 7/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 6/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 6/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 7/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 6/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.33 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL1162681 | 1.00 | SLC7A5 (0.51) | SLC7A5SLC1A2SLC1A3SLC1A1GRIK1 | |
| Leucine SCHEMBL2545364 | 0.97 | SLC7A5 (0.55) | SLC7A5SLC1A2SLC1A3SLC1A1GRIK1 | |
| Leucine SCHEMBL16540381 | 0.96 | SLC7A5 (0.47) | SLC7A5SLC1A2SLC1A3SLC1A1GRIK1 | |
| Leucine SCHEMBL16540382 | 0.96 | SLC7A5 (0.47) | SLC7A5SLC1A2SLC1A3SLC1A1GRIK1 | |
| Leucine SCHEMBL2550681 | 0.96 | SLC7A5 (0.56) | SLC7A5SLC1A2SLC1A3SLC1A1GRIK1 | |
| Leucine SCHEMBL1863461 | 0.94 | SLC7A5 (0.58) | SLC7A5SLC1A2SLC1A3SLC1A1GRIK1 | |
| Leucine SCHEMBL7759799 | 0.94 | SLC7A5 (0.58) | SLC7A5SLC1A2SLC1A3SLC1A1GRIK1 | |
| Leucine SCHEMBL21747499 | 0.93 | SLC7A5 (0.60) | SLC7A5SLC1A2SLC1A3SLC1A1GRIK1 | |
| Leucine SCHEMBL3497103 | 0.93 | SLC7A5 (0.60) | SLC7A5SLC1A2SLC1A3SLC1A1GRIK1 | |
| Leucine SCHEMBL5494110 | 0.93 | SLC7A5 (0.60) | SLC7A5SLC1A2SLC1A3SLC1A1GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3074415-A1 | NOVEL ULTRASHORT HYDROPHOBIC PEPTIDES THAT SELF-ASSEMBLE INTO NANOFIBROUS HYDROGELS AND THEIR USES | Agency For Science, Technology And Research (SG) | 2016-10-05 | — | — | EP | claimed |
| WO-2015080670-A1 | NOVEL ULTRASHORT HYDROPHOBIC PEPTIDES THAT SELF-ASSEMBLE INTO NANOFIBROUS HYDROGELS AND THEIR USES | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2015-06-04 | — | — | WO | claimed |
| CN-105189532-B | Self-assembled ultrashort peptide hydrogels for wound healing, skin care and cosmetic applications | 新加坡科技研究局 | 2020-11-03 | — | — | CN | disclosed |
| US-10293083-B2 | Crosslinked peptide hydrogels | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2019-05-21 | — | — | US | disclosed |
| US-10286111-B2 | Crosslinked peptide hydrogels | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2019-05-14 | — | — | US | disclosed |
| US-10286110-B2 | Crosslinked peptide hydrogels | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2019-05-14 | — | — | US | disclosed |
| US-10179194-B2 | Self-assembling peptides, peptidomimetics and peptidic conjugates as building blocks for biofabrication and printing | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2019-01-15 | — | — | US | disclosed |
| US-10117946-B2 | Self-assembling ultrashort peptides modified with bioactive agents by click chemistry | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2018-11-06 | — | — | US | disclosed |
| US-10071183-B2 | Amphiphilic linear peptide/peptoid and hydrogel comprising the same | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2018-09-11 | — | — | US | disclosed |
| EP-2958933-B1 | CROSSLINKED PEPTIDE HYDROGELS | AGENCY SCIENCE TECH & RES (SG) | 2018-08-22 | — | — | EP | disclosed |
| US-9925307-B2 | Crosslinked peptide hydrogels | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2018-03-27 | — | — | US | disclosed |
| US-8999916-B2 | Crosslinked peptide hydrogels | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2015-04-07 | — | — | US | disclosed |
| WO-2014116187-A1 | CROSSLINKED PEPTIDE HYDROGELS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2014-07-31 | — | — | WO | disclosed |
| WO-2014104981-A1 | SELF-ASSEMBLED ULTRASHORT PEPTIDES HYDROGELS FOR WOUND HEALING, SKIN CARE AND COSMETICS APPLICATIONS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2014-07-03 | — | — | WO | disclosed |
| WO-2014104974-A2 | SELF-ASSEMBLING ULTRASHORT PEPTIDES MODIFIED WITH BIOACTIVE AGENTS BY CLICK CHEMISTRY | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2014-07-03 | — | — | WO | disclosed |
| US-20130267455-A1 | CROSSLINKED PEPTIDE HYDROGELS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2013-10-10 | — | — | US | disclosed |
| EP-2552938-A1 | AMPHIPHILIC LINEAR PEPTIDE/PEPTOID AND HYDROGEL COMPRISING THE SAME | Agency for Science, Technology And Research (SG) | 2013-02-06 | — | — | EP | disclosed |
| US-20130023460-A1 | AMPHIPHILIC LINEAR PEPTIDE/PEPTOID AND HYDROGEL COMPRISING THE SAME | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2013-01-24 | — | — | US | disclosed |
| WO-2011123061-A1 | AMPHIPHILIC LINEAR PEPTIDE/PEPTOID AND HYDROGEL COMPRISING THE SAME | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2011-10-06 | — | — | WO | disclosed |
| WO-2011017294-A1 | HUMAN ANTI-RANKL ANTIBODIES | SCHERING CORPORATION (US) | 2011-02-10 | — | — | WO | disclosed |