SCHEMBL11632533

SCHEMBL11632533

Fc1ccc(C(CCn2ccnc2)SCc2ccc(Cl)cc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 5/20 0.56
CYP3A4 P08684 3/20 0.54
CYP1A2 P05177 2/20 0.54
CYP2D6 P10635 2/20 0.54
CYP2C9 P11712 2/20 0.54
CYP2C19 P33261 2/20 0.54
USP2 O75604 2/20 0.54
SMN1; SMN2 Q16637 2/20 0.54
TDP1 Q9NUW8 2/20 0.54
IDO1 P14902 2/20 0.54
ALOX15 P16050 1/20 0.54
NR1I2 O75469 1/20 0.54
NR3C1 P04150 1/20 0.54
FYN P06241 1/20 0.54
CHRM4 P08173 1/20 0.54
CHRM5 P08912 1/20 0.54
ADRA2A P08913 1/20 0.54
ADORA3 P0DMS8 1/20 0.54
CHRM1 P11229 1/20 0.54
DRD2 P14416 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11633847 0.94 CYP3A4 (0.59) CYP19A1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL11637149 0.91 CYP19A1 (0.50) CYP19A1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL11699651 0.90 CYP3A4 (0.66) CYP19A1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL11632637 0.88 CYP3A4 (0.58) CYP19A1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL11632167 0.85 IDO1 (0.70) CYP19A1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL11632920 0.84 CYP19A1 (0.59) CYP19A1IDO1CYP11B1CYP11B2TP53
SCHEMBL11638108 0.83 CYP3A4 (0.53) CYP19A1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL11696871 0.83 CYP3A4 (0.73) CYP19A1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL11635545 0.80 CYP19A1 (0.52) CYP19A1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL11633078 0.80 CYP19A1 (0.55) CYP19A1CYP3A4CYP1A2CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4078071-A FUNGICIDES, BACTERICIDES, ANTIPROTOZOA AGENTS SYNTEX (U.S.A.) INC. (US) 1978-03-07 US disclosed