Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | INPP5D | Q92835 | 2/20 | 0.98 |
| ▸ | CDC25A | P30304 | 4/20 | 0.65 |
| ▸ | BCHE | P06276 | 1/20 | 0.64 |
| ▸ | ACHE | P22303 | 1/20 | 0.64 |
| ▸ | POLA1 | P09884 | 1/20 | 0.64 |
| ▸ | OSBP | P22059 | 1/20 | 0.59 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.57 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.57 |
| ▸ | ST6GAL1 | P15907 | 1/20 | 0.57 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | CASP7 | P55210 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8021037 | 1.00 | CYP2D6 (1.00) | CYP2D6CYP2C19INPP5DCDC25ABCHE | |
| SCHEMBL20004917 | 1.00 | CYP2D6 (1.00) | CYP2D6CYP2C19INPP5DCDC25ABCHE | |
| SCHEMBL18541453 | 1.00 | CYP2D6 (1.00) | CYP2D6CYP2C19INPP5DCDC25ABCHE | |
| SCHEMBL21946613 | 1.00 | CYP2D6 (1.00) | CYP2D6CYP2C19INPP5DCDC25ABCHE | |
| SCHEMBL23016826 | 1.00 | CYP2D6 (1.00) | CYP2D6CYP2C19INPP5DCDC25ABCHE | |
| SCHEMBL1163573 | 1.00 | CYP2D6 (1.00) | CYP2D6CYP2C19INPP5DCDC25ABCHE | |
| SCHEMBL23645781 | 1.00 | CYP2D6 (1.00) | CYP2D6CYP2C19INPP5DCDC25ABCHE | |
| SCHEMBL22712829 | 1.00 | CYP2D6 (1.00) | CYP2D6CYP2C19INPP5DCDC25ABCHE | |
| SCHEMBL24104271 | 1.00 | CYP2D6 (1.00) | CYP2D6CYP2C19INPP5DCDC25ABCHE | |
| SCHEMBL21589991 | 1.00 | CYP2D6 (1.00) | CYP2D6CYP2C19INPP5DCDC25ABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889631-B2 | Disruptors of early/recycling endosomes | THE UNIVERSITY OF KANSAS (US) | 2014-11-18 | — | — | US | claimed |
| WO-2010022051-A2 | DISRUPTORS OF EARLY/RECYCLING ENDOSOMES | UNIVERSITY OF KANSAS (US) | 2010-02-25 | — | — | WO | claimed |
| US-20100041773-A1 | DISRUPTORS OF EARLY/RECYCLING ENDOSOMES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-02-18 | — | — | US | claimed |
| EP-3581563-B1 | SHIP INHIBITORS AND USES THEREOF | THE RESEARCH FOUNDATION OF THE STATE UNIV OF NEW YORK (US) | 2023-06-28 | — | — | EP | disclosed |
| US-20220162254-A1 | SHIP INHIBITORS AND USES THEREOF | UNIV NEW YORK STATE RES FOUND (US) | 2022-05-26 | — | — | US | disclosed |
| US-11319336-B2 | Ship inhibitors and uses thereof | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK | 2022-05-03 | — | — | US | disclosed |
| US-20220023315-A1 | METHODS OF ACTIVATING MICROGLIAL CELLS | UNIV NEW YORK STATE RES FOUND (US) | 2022-01-27 | — | — | US | disclosed |
| EP-3695841-A2 | SHIP INHIBITION TO COMBAT OBESITY | The Research Foundation for the State University of New York (US) | 2020-08-19 | — | — | EP | disclosed |
| EP-2556055-B1 | SHIP INHIBITORS AND USES THEREOF | THE RESEARCH FOUNDATION OF THE STATE UNIV OF NEW YORK (US) | 2019-07-31 | — | — | EP | disclosed |
| US-9636419-B2 | Targeting multiple receptors on a cell surface for specific cell targeting | The Universit of Kansas (US) | 2017-05-02 | — | — | US | disclosed |
| US-20170051006-A1 | SHIP INHIBITORS AND USES THEREOF | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2017-02-23 | — | — | US | disclosed |
| US-8889631-B2 | Disruptors of early/recycling endosomes | THE UNIVERSITY OF KANSAS (US) | 2014-11-18 | — | — | US | disclosed |
| US-8637468-B2 | Synthetic cholesterylamine-linker derivatives for agent delivery into cells | THE UNIVERSITY OF KANSAS (US) | 2014-01-28 | — | — | US | disclosed |
| US-20130102577-A1 | SHIP INHIBITORS AND USES THEREOF | THE RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK (US) | 2013-04-25 | — | — | US | disclosed |
| US-20130102577-A1 | SHIP INHIBITORS AND USES THEREOF | THE RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK (US) | 2013-04-25 | — | — | US | disclosed |
| US-20120208771-A1 | SYNTHETIC CHOLESTERYLAMINE-LINKER DERIVATIVES FOR AGENT DELIVERY INTO CELLS | THE PENN STATE RESEARCH FOUNDATION (US) | 2012-08-16 | — | — | US | disclosed |
| WO-2011127465-A2 | SHIP INHIBITORS AND USES THEREOF | THE RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK (US) | 2011-10-13 | — | — | WO | disclosed |
| WO-2011019942-A2 | SYNTHETIC CHOLESTERYLAMINE-LINKER DERIVATIVES FOR AGENT DELIVERY INTO CELLS | UNIVERSITY OF KANSAS (US) | 2011-02-17 | — | — | WO | disclosed |
| WO-2010022051-A2 | DISRUPTORS OF EARLY/RECYCLING ENDOSOMES | UNIVERSITY OF KANSAS (US) | 2010-02-25 | — | — | WO | disclosed |
| US-20100041773-A1 | DISRUPTORS OF EARLY/RECYCLING ENDOSOMES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208771-A1 | SYNTHETIC CHOLESTERYLAMINE-LINKER DERIVATIVES FOR AGENT DELIVERY INTO CELLS | NPC1L1, CETP, CYP46A1 | CYP2D6 3525/4885CYP2C19 2914/4885INPP5D 2435/4885 |
| US-20130102577-A1 | SHIP INHIBITORS AND USES THEREOF | PPP5C, DUSP1, DUSP5 | CYP2D6 3990/4885CYP2C19 4686/4885INPP5D 53/4885 |
| US-11319336-B2 | Ship inhibitors and uses thereof | PPP5C, DUSP1, DUSP5 | CYP2D6 3990/4885CYP2C19 4686/4885INPP5D 53/4885 |
| US-20220023315-A1 | METHODS OF ACTIVATING MICROGLIAL CELLS | LPCAT3, PLAAT2, PLA2G4B | CYP2D6 4879/4885CYP2C19 4881/4885INPP5D 50/4885 |
| US-20220162254-A1 | SHIP INHIBITORS AND USES THEREOF | PPP5C, DUSP1, DUSP5 | CYP2D6 3990/4885CYP2C19 4686/4885INPP5D 53/4885 |
| US-20100041773-A1 | DISRUPTORS OF EARLY/RECYCLING ENDOSOMES | EEA1, NSF, LAMP2 | CYP2D6 4832/4885CYP2C19 4885/4885INPP5D 1185/4885 |
| US-20170051006-A1 | SHIP INHIBITORS AND USES THEREOF | PPP5C, DUSP1, DUSP5 | CYP2D6 3990/4885CYP2C19 4686/4885INPP5D 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.