Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11858997 | 0.87 | GRIN1 (0.44) | GRIN1GRIN2BPOLBKDM4EALDH1A1 | |
| SCHEMBL11863918 | 0.85 | GRIN1 (0.46) | GRIN1GRIN2BPOLBKDM4EALDH1A1 | |
| SCHEMBL11156465 | 0.84 | GRIN1 (0.42) | GRIN1GRIN2BALDH1A1 | |
| SCHEMBL11865450 | 0.84 | GRIN1 (0.42) | GRIN1GRIN2BPOLBKDM4EALDH1A1 | |
| SCHEMBL11862223 | 0.83 | GRIN1 (0.45) | GRIN1GRIN2BKDM4EALDH1A1MAPT | |
| SCHEMBL11858985 | 0.83 | GRIN1 (0.42) | GRIN1GRIN2B | |
| SCHEMBL11866771 | 0.83 | GRIN1 (0.42) | GRIN1GRIN2BPOLBKDM4EALDH1A1 | |
| SCHEMBL11167513 | 0.82 | MAPT (0.57) | KDM4EMAPTTP53LMNA | |
| SCHEMBL11868110 | 0.81 | KCNH2 (0.44) | KDM4EALDH1A1MAPTTP53LMNA | |
| SCHEMBL3280114 | 0.81 | PDE4A (0.51) | KDM4EALDH1A1MAPTTP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3950526-A | Quinazoline derivatives in pharmaceutical compositions for treating pain and inflammation | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-04-13 | — | — | US | claimed |
| US-4096144-A | Process for preparing quinazolinone derivatives and their 2-(N-mono-substituted amino)-phenyl ketone intermediate derivatives | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1978-06-20 | — | — | US | disclosed |
| US-3950526-A | Quinazoline derivatives in pharmaceutical compositions for treating pain and inflammation | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-04-13 | — | — | US | disclosed |