Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GPX4 | P36969 | 1/20 | 0.38 |
| ▸ | ICMT | O60725 | 1/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11586641 | 1.00 | NPC1 (0.50) | NPC1RAB9APAX8JAK2KCNH2 | |
| SCHEMBL11587549 | 1.00 | NPC1 (0.50) | NPC1RAB9APAX8JAK2KCNH2 | |
| SCHEMBL11642255 | 0.93 | NPC1 (0.41) | NPC1RAB9APAX8JAK2KCNH2 | |
| SCHEMBL11639542 | 0.88 | NPC1 (0.45) | NPC1RAB9APAX8JAK2KCNH2 | |
| SCHEMBL11638360 | 0.88 | NPC1 (0.45) | NPC1RAB9APAX8JAK2KCNH2 | |
| SCHEMBL9289411 | 0.85 | TP53 (0.43) | NPC1RAB9APAX8JAK2KCNH2 | |
| SCHEMBL28965613 | 0.84 | NPC1 (0.47) | NPC1RAB9APAX8JAK2KCNH2 | |
| SCHEMBL11637427 | 0.84 | NPC1 (0.47) | NPC1RAB9APAX8JAK2KCNH2 | |
| SCHEMBL11634718 | 0.84 | NPC1 (0.47) | NPC1RAB9APAX8JAK2KCNH2 | |
| SCHEMBL27661446 | 0.83 | NPC1 (0.42) | NPC1RAB9APAX8JAK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4076849-A | AROMATIC SECONDARY AMINES | CANADA PACKERS LIMITED (CA) | 1978-02-28 | — | — | US | disclosed |