Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GRM5 | P41594 | 3/20 | 0.47 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.38 |
| ▸ | GFRA3 | O60609 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11643326 | 0.90 | GRM5 (0.58) | MEN1RAB9AKMT2AGRM5KDM6B | |
| SCHEMBL11643668 | 0.80 | MEN1 (0.44) | MEN1RAB9AKMT2AGRM5KDM6B | |
| SCHEMBL11643411 | 0.80 | KDM6B (0.44) | MEN1RAB9AKMT2AKDM6BKDM4C | |
| SCHEMBL11642866 | 0.76 | MEN1 (0.40) | MEN1RAB9AKMT2AKDM6BKDM4C | |
| SCHEMBL11646101 | 0.75 | GRM5 (0.46) | MEN1RAB9AKMT2AGRM5KDM6B | |
| SCHEMBL11647451 | 0.74 | KDM6B (0.45) | MEN1RAB9AKMT2AGRM5KDM6B | |
| SCHEMBL11648533 | 0.74 | KDM6B (0.45) | MEN1RAB9AKMT2AGRM5KDM6B | |
| SCHEMBL11644005 | 0.74 | KDM6B (0.50) | MEN1RAB9AKMT2AGRM5KDM6B | |
| SCHEMBL11641009 | 0.74 | MEN1 (0.42) | MEN1RAB9AKMT2AKDM6BKDM4C | |
| SCHEMBL28524205 | 0.73 | MEN1 (0.44) | MEN1RAB9AKMT2AASIC3GFRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4117135-A | NOVEL 5,6,7,8-TETRAHYDRO-5-QUINOLINES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | SCHERING, A.G. | 1978-09-26 | — | — | US | disclosed |