Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | USP2 | O75604 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | GPBAR1 | Q8TDU6 | 8/20 | 0.64 |
| ▸ | SLC10A2 | Q12908 | 2/20 | 0.64 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.64 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.64 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.64 |
| ▸ | CA1 | P00915 | 6/20 | 0.55 |
| ▸ | CA2 | P00918 | 6/20 | 0.55 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | VDR | P11473 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.49 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17090568 | 0.86 | MAPT (0.69) | MAPTMEN1KMT2AUSP2LMNA | |
| SCHEMBL22699678 | 0.85 | MAPT (0.83) | MAPTMEN1KMT2AUSP2LMNA | |
| SCHEMBL4971166 | 0.85 | MAPT (0.83) | MAPTMEN1KMT2AUSP2LMNA | |
| SCHEMBL19705475 | 0.84 | GPBAR1 (0.67) | MAPTMEN1KMT2AUSP2LMNA | |
| SCHEMBL20012396 | 0.84 | GPBAR1 (0.67) | MAPTMEN1KMT2AUSP2LMNA | |
| SCHEMBL20008828 | 0.84 | GPBAR1 (0.67) | MAPTMEN1KMT2AUSP2LMNA | |
| SCHEMBL1656466 | 0.84 | GPBAR1 (0.81) | MAPTMEN1KMT2AUSP2LMNA | |
| SCHEMBL15145513 | 0.84 | GPBAR1 (0.81) | MAPTMEN1KMT2AUSP2LMNA | |
| SCHEMBL20012664 | 0.83 | MAPT (0.62) | MAPTMEN1KMT2AUSP2LMNA | |
| SCHEMBL20008824 | 0.83 | MAPT (0.62) | MAPTMEN1KMT2AUSP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4104285-A | OF NORCHOLANIC ACID, BISNORCHOLANIC ACID, OR ETIOCHOLANIC ACID, STEROIDS, BILE FLOW STIMULATORS, ANTILIPEMIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1978-08-01 | — | — | US | claimed |
| US-4104285-A | OF NORCHOLANIC ACID, BISNORCHOLANIC ACID, OR ETIOCHOLANIC ACID, STEROIDS, BILE FLOW STIMULATORS, ANTILIPEMIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1978-08-01 | — | — | US | disclosed |