Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.49 |
| ▸ | CCR6 | P51684 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4131672 | 0.82 | KDM4E (0.54) | KDM4EMAPK1TDP1L3MBTL1MDM2 | |
| SCHEMBL4434197 | 0.82 | MDM2 (0.67) | KDM4EMAPK1TDP1L3MBTL1MDM2 | |
| SCHEMBL29232726 | 0.81 | CCR6 (0.56) | KDM4EMAPK1TDP1L3MBTL1MDM2 | |
| SCHEMBL8946445 | 0.81 | MDM2 (0.68) | KDM4EMAPK1TDP1L3MBTL1MDM2 | |
| SCHEMBL9784691 | 0.81 | KDM4E (0.55) | KDM4EMAPK1TDP1L3MBTL1MDM2 | |
| SCHEMBL4132138 | 0.77 | MDM2 (0.60) | KDM4EMAPK1TDP1L3MBTL1MDM2 | |
| SCHEMBL28021689 | 0.75 | PARP1 (0.62) | KDM4EMAPK1TDP1L3MBTL1MDM2 | |
| SCHEMBL28509330 | 0.74 | MDM2 (0.60) | KDM4EMAPK1TDP1L3MBTL1MDM2 | |
| SCHEMBL31091350 | 0.74 | MDM2 (0.60) | KDM4EMAPK1TDP1L3MBTL1MDM2 | |
| SCHEMBL28516955 | 0.74 | MDM2 (0.60) | KDM4EMAPK1TDP1L3MBTL1MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4117135-A | NOVEL 5,6,7,8-TETRAHYDRO-5-QUINOLINES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | SCHERING, A.G. | 1978-09-26 | — | — | US | disclosed |