Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 4/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | SLC37A4 | O43826 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11659958 | 0.99 | AKR1B1 (0.46) | AKR1B1MAPK14MAPTMEN1KMT2A | |
| SCHEMBL11663094 | 0.96 | AKR1B1 (0.47) | AKR1B1MAPK14MAPTMEN1KMT2A | |
| SCHEMBL11654836 | 0.81 | AKR1B1 (0.50) | AKR1B1MAPK14MAPTMEN1KMT2A | |
| SCHEMBL11845419 | 0.77 | AKR1B1 (0.55) | AKR1B1MAPK14MAPTSMN1; SMN2PTPN11 | |
| SCHEMBL11662112 | 0.77 | AKR1B1 (0.55) | AKR1B1MAPK14MAPTSMN1; SMN2PTPN11 | |
| SCHEMBL11661514 | 0.76 | AKR1B1 (0.56) | AKR1B1MAPK14MAPTMEN1KMT2A | |
| SCHEMBL11570176 | 0.76 | AKR1B1 (0.64) | AKR1B1MAPK14PTPN11KDM4ETSHR | |
| SCHEMBL11824625 | 0.76 | AKR1B1 (0.64) | AKR1B1MAPK14PTPN11KDM4ETSHR | |
| SCHEMBL11570278 | 0.76 | AKR1B1 (0.64) | AKR1B1MAPK14PTPN11KDM4ETSHR | |
| SCHEMBL11827878 | 0.76 | AKR1B1 (0.64) | AKR1B1MAPK14PTPN11KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4066663-A | 6,11-Dihydrodibenzo-[b. e.]-thiepin-11-one-3-aldehyde and 3-acetal derivatives | SYNTEX (U.S.A.) INC. (US) | 1978-01-03 | — | — | US | claimed |
| US-4066663-A | 6,11-Dihydrodibenzo-[b. e.]-thiepin-11-one-3-aldehyde and 3-acetal derivatives | SYNTEX (U.S.A.) INC. (US) | 1978-01-03 | — | — | US | disclosed |