Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MIF | P14174 | 4/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | CASP3 | P42574 | 2/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11663094 | 0.83 | AKR1B1 (0.47) | AKR1B1MAPK14ACHEMAPTALDH1A1 | |
| SCHEMBL11659958 | 0.82 | AKR1B1 (0.46) | AKR1B1MAPK14ACHEMAPTALDH1A1 | |
| SCHEMBL11711522 | 0.81 | AKR1B1 (0.56) | AKR1B1MAPK14ACHEMAPTALDH1A1 | |
| SCHEMBL11657293 | 0.81 | AKR1B1 (0.45) | AKR1B1MAPK14ACHEMAPTMEN1 | |
| SCHEMBL11761145 | 0.77 | AKR1B1 (0.55) | AKR1B1MAPK14ACHEALDH1A1MIF | |
| SCHEMBL2007673 | 0.73 | AKR1B1 (0.57) | AKR1B1MAPK14ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL32670916 | 0.73 | ALDH1A1 (0.51) | AKR1B1MAPK14ACHEMAPTALDH1A1 | |
| SCHEMBL31123671 | 0.73 | ACHE (0.59) | AKR1B1MAPK14ACHEALDH1A1MEN1 | |
| SCHEMBL31510701 | 0.73 | ACHE (0.59) | AKR1B1MAPK14ACHEALDH1A1MEN1 | |
| SCHEMBL86279 | 0.73 | ACHE (0.59) | AKR1B1MAPK14ACHEALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4066663-A | 6,11-Dihydrodibenzo-[b. e.]-thiepin-11-one-3-aldehyde and 3-acetal derivatives | SYNTEX (U.S.A.) INC. (US) | 1978-01-03 | — | — | US | claimed |
| US-4066663-A | 6,11-Dihydrodibenzo-[b. e.]-thiepin-11-one-3-aldehyde and 3-acetal derivatives | SYNTEX (U.S.A.) INC. (US) | 1978-01-03 | — | — | US | disclosed |