Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 4/20 | 0.53 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.47 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.47 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1166861 | 0.91 | FPR2 (0.55) | FPR2HCRTR2HCRTR1CACNA1GCACNA1H | |
| SCHEMBL1166044 | 0.91 | HCRTR2 (0.56) | FPR2HCRTR2HCRTR1CACNA1GCACNA1H | |
| SCHEMBL1166542 | 0.90 | FPR2 (0.54) | FPR2HCRTR2HCRTR1NPC1TP53 | |
| SCHEMBL1167410 | 0.89 | FPR2 (0.56) | FPR2HCRTR2HCRTR1CACNA1GCACNA1H | |
| SCHEMBL1166487 | 0.88 | HCRTR1 (0.57) | FPR2HCRTR2HCRTR1NPC1RAB9A | |
| SCHEMBL1165978 | 0.88 | FPR2 (0.57) | FPR2HCRTR2HCRTR1CACNA1GCACNA1H | |
| SCHEMBL1166987 | 0.87 | FPR2 (0.68) | FPR2HCRTR2HCRTR1CACNA1GCACNA1H | |
| SCHEMBL1166816 | 0.85 | HCRTR2 (0.69) | HCRTR2HCRTR1 | |
| SCHEMBL1166163 | 0.84 | HCRTR2 (0.57) | FPR2HCRTR2HCRTR1NPC1TP53 | |
| SCHEMBL1166934 | 0.84 | HCRTR2 (0.58) | FPR2HCRTR2HCRTR1TP53NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110034516-A1 | AMINOPYRAZOLE DERIVATIVES | ACTELION (CH) | 2011-02-10 | — | — | US | claimed |
| US-20110034516-A1 | AMINOPYRAZOLE DERIVATIVES | ACTELION (CH) | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034516-A1 | AMINOPYRAZOLE DERIVATIVES | CYP3A43, CYP1A2, CYP3A5 | FPR2 1074/4885HCRTR2 2700/4885HCRTR1 2862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.