Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NNMT | P40261 | 3/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.36 |
| ▸ | MB | P02144 | 1/20 | 0.36 |
| ▸ | XIAP | P98170 | 1/20 | 0.35 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.34 |
| ▸ | P4HA1 | P13674 | 3/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.33 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14387476 | 0.83 | MAP4K4 (0.42) | HTTCYP11B1CYP11B2GSK3AGSK3B | |
| SCHEMBL25789801 | 0.77 | NNMT (0.49) | NNMTMGAMP4HA1P4HTMMIF | |
| SCHEMBL29712705 | 0.77 | NNMT (0.49) | NNMTMGAMP4HA1P4HTMMIF | |
| SCHEMBL1255178 | 0.77 | GSK3A (0.40) | MBXIAPBIRC2CYP11B1CYP11B2 | |
| SCHEMBL16168388 | 0.77 | NNMT (0.41) | NNMTMGAMP4HA1P4HTMMIF | |
| SCHEMBL28617969 | 0.76 | NNMT (0.47) | NNMTMGAMP4HA1P4HTMMIF | |
| SCHEMBL16563482 | 0.76 | AHR (0.39) | MBXIAPBIRC2CYP11B1CYP11B2 | |
| SCHEMBL16564067 | 0.76 | CYP11B1 (0.37) | SMYD3MBXIAPBIRC2CYP11B1 | |
| SCHEMBL14387097 | 0.76 | CYP11B1 (0.37) | MBXIAPBIRC2CYP11B1CYP11B2 | |
| SCHEMBL1601643 | 0.76 | CYP11B1 (0.37) | MBXIAPBIRC2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4091219-A | ANTIINFLAMMATORY AGENTS, CNS DEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1978-05-23 | — | — | US | disclosed |
| US-4077955-A | ANTIINFLAMMATORY, CNS DEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1978-03-07 | — | — | US | disclosed |