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NNMT

Nicotinamide N-methyltransferase · P40261 · NNMT on Sugi Atlas →

15,035 patent compounds predicted against NNMT, 6,270 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL2124781 SCHEMBL2124781 0.59 9/20
SCHEMBL2226474 SCHEMBL2226474 0.51 9/20
SCHEMBL71905 SCHEMBL71905 1.00 7/20
SCHEMBL669121 SCHEMBL669121 0.52 7/20
SCHEMBL1745778 SCHEMBL1745778 0.52 7/20
SCHEMBL2087026 SCHEMBL2087026 0.50 7/20
SCHEMBL883870 SCHEMBL883870 0.45 6/20
Sinefungin Sinefungin (SCHEMBL167609) 1.00 5/20
SCHEMBL1680658 SCHEMBL1680658 0.73 5/20
SCHEMBL1515510 SCHEMBL1515510 0.72 5/20
SCHEMBL2287296 SCHEMBL2287296 0.66 5/20
SCHEMBL2287307 SCHEMBL2287307 0.66 5/20
SCHEMBL2287316 SCHEMBL2287316 0.66 5/20
SCHEMBL805652 SCHEMBL805652 0.64 5/20
SCHEMBL384113 SCHEMBL384113 0.61 5/20
SCHEMBL1536039 SCHEMBL1536039 0.59 5/20
Adenosine Adenosine (SCHEMBL225269) 0.57 5/20
Adenosine Adenosine (SCHEMBL225271) 0.57 5/20
SCHEMBL1515561 SCHEMBL1515561 0.56 5/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL726309) 0.51 5/20

Clinical trials — most relevant to NNMT by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Efficacy and Safety of Oral Nicotinamide as an Adjunctive Therapy in Patients With Sepsis PHASE4NOT_YET_RECRUITING
cindilizumab + Bevacizumab + Coenzyme I for Injection in Unresectable Hepatocellular Carcinoma PHASE4UNKNOWN
Stem Cell Transplantation With NiCord® (Omidubicel) vs Standard UCB in Patients With Leukemia, Lymphoma, and MDS PHASE3COMPLETED
Sirtuin-NAD Activator in Alzheimer's Disease PHASE1/PHASE2ACTIVE_NOT_RECRUITING
Effects of Vitamin B3 in Patients With Ataxia Telangiectasia PHASE2COMPLETED
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome PHASE1/PHASE2COMPLETED
A Clinical Study of NAD in the Treatment of Immune Thrombocytopenia PHASE1/PHASE2RECRUITING
Effects of Nicotinamide Riboside on the Clinical Outcome of Covid-19 in the Elderly PHASE2WITHDRAWN
Study of the Efficacy and Safety of Nicotinamide in Patients With Friedreich Ataxia PHASE2WITHDRAWN
Nicotinamide Riboside Supplementation for Treating Arterial Stiffness and Elevated Systolic Blood Pressure in Patients With Moderate to Severe CKD PHASE2ACTIVE_NOT_RECRUITING
Nicotinamide Riboside in Systolic Heart Failure PHASE1/PHASE2COMPLETED
Nitrites, Skeletal Muscle Mitochondrial Bioenergetics, and Physical Activity in Old Age PHASE2COMPLETED
NAD-brain: a Pharmacokinetic Study of NAD Replenishment Therapy PHASE1COMPLETED
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults PHASE1RECRUITING
Phase I Trial of 4'-Thio-2'-Deoxycytidine (TdCyd) in Patients With Advanced Solid Tumors PHASE1COMPLETED
5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors PHASE1RECRUITING
Nicotinamide Riboside in LVAD Recipients EARLY_PHASE1COMPLETED
Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia EARLY_PHASE1ACTIVE_NOT_RECRUITING
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression nanCOMPLETED
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside nanUNKNOWN
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer nanUNKNOWN
Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD nanNOT_YET_RECRUITING
NOPARK Open Label Extension Study nanACTIVE_NOT_RECRUITING
Thermogenic Silencer Regulatory Factors in Humans nanACTIVE_NOT_RECRUITING
Pharmacodynamics and Tolerance of Nicotinamide Mononucleotide (NMN, 400mg/Day) in Healthy Adults nanCOMPLETED
Effect of NMN on Muscle Recovery and Physical Capacity in Healthy Volunteers With Moderate Physical Activity nanCOMPLETED
Mitochondrial Health and Hemodynamic Instability Related to Renal Replacement Therapy in Critically Ill Patients nanUNKNOWN
Study to Evaluate the Effect of Nicotinamide Riboside on Immunity nanCOMPLETED
Project SIRT6 Activator nanRECRUITING
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a NNMT binder may also engage these)

ProteinNameSimilarity
Q06AV1 — 1.000 Q06AV1 →
O55239 — 1.000 O55239 →
Q5RFR7 — 1.000 Q5RFR7 →
O97972 — 0.997 O97972 →
INMT Indolethylamine N-methyltransferase 0.995 landscape →
P40936 — 0.992 P40936 →
P10937 — 0.980 P10937 →
Q99487 — 0.976 Q99487 →
Q9QX22 — 0.975 Q9QX22 →
P10938 — 0.975 P10938 →
Q8VDG7 — 0.974 Q8VDG7 →
Q5RFM7 — 0.974 Q5RFM7 →
Q17QQ2 — 0.973 Q17QQ2 →
P79106 — 0.973 P79106 →
Q96GJ1 — 0.973 Q96GJ1 →
Q5R8R3 — 0.973 Q5R8R3 →
Q3BCR3 — 0.972 Q3BCR3 →
P83006 — 0.972 P83006 →
PNMT Phenylethanolamine N-methyltransferase 0.972 landscape →
Q8BQJ6 — 0.971 Q8BQJ6 →
Q921K8 — 0.971 Q921K8 →
A5PJN5 — 0.971 A5PJN5 →
TPMT Thiopurine S-methyltransferase 0.971 landscape →
Q7Z7L1 — 0.971 Q7Z7L1 →
Q6EIC1 — 0.971 Q6EIC1 →
P40935 — 0.970 P40935 →
Q3UZW7 — 0.970 Q3UZW7 →
Q6NTR1 — 0.970 Q6NTR1 →
P0C5J1 — 0.970 P0C5J1 →
Q9QXS7 — 0.970 Q9QXS7 →