Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 6/20 | 1.00 |
| ▸ | MEN1 | O00255 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | HTT | P42858 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.67 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.67 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.67 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29158467 | 0.89 | MAPT (0.79) | MAPTKMT2AMEN1LMNAHTT | |
| SCHEMBL29158527 | 0.89 | MAPT (0.79) | MAPTKMT2AMEN1LMNAHTT | |
| SCHEMBL1784868 | 0.87 | MEN1 (0.75) | MAPTKMT2AMEN1LMNAHTT | |
| SCHEMBL1784866 | 0.87 | MEN1 (0.75) | MAPTKMT2AMEN1LMNAHTT | |
| SCHEMBL2843795 | 0.83 | MAPT (0.71) | MAPTKMT2AMEN1LMNAHTT | |
| SCHEMBL2843794 | 0.83 | MAPT (0.71) | MAPTKMT2AMEN1LMNAHTT | |
| SCHEMBL11476504 | 0.81 | MAPT (0.69) | MAPTKMT2AMEN1LMNAHTT | |
| SCHEMBL11476503 | 0.81 | MAPT (0.69) | MAPTKMT2AMEN1LMNAHTT | |
| SCHEMBL8991793 | 0.81 | MAPT (0.69) | MAPTKMT2AMEN1LMNAHTT | |
| SCHEMBL14573795 | 0.81 | MAPT (0.68) | MAPTKMT2AMEN1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017606-B2 | Therapy for bacteria infections other than Mycibacterium infections; antibiotic resistance | JANSSEN PHARMACEUTICA NV (BE) | 2011-09-13 | — | — | US | disclosed |
| US-20110124870-A1 | NOVEL MYCOBACTERIAL INHIBITORS | JANSSEN-CILAG (FR) | 2011-05-26 | — | — | US | disclosed |
| US-7902225-B2 | Mycobacterial inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2011-03-08 | — | — | US | disclosed |
| US-20080255116-A1 | Therapy for bacteria infections other than Mycibacterium infections; antibiotic resistance | JANSSEN PHARMACEUTICA N.V. | 2008-10-16 | — | — | US | disclosed |
| US-20070093478-A1 | Novel mycobacterial inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-26 | — | — | US | disclosed |
| US-4066764-A | 1,4-Dihydro-2H-isoquinoline derivatives | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-01-03 | — | — | US | disclosed |
| US-4049655-A | 1,4-Dihydro-2H-isoquinoline derivatives | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-09-20 | — | — | US | disclosed |
| US-3980655-A | Basically substituted 1,4-dihydro-2H-isoquinoline derivatives and process for preparing them | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124870-A1 | NOVEL MYCOBACTERIAL INHIBITORS | NQO2, NAT1, HRH1 | MAPT 904/4885KMT2A 3862/4885MEN1 1507/4885 |
| US-20070093478-A1 | Novel mycobacterial inhibitors | NQO2, NAT1, HRH1 | MAPT 854/4885KMT2A 3905/4885MEN1 1792/4885 |
| US-20080255116-A1 | Therapy for bacteria infections other than Mycibacterium infections; antibiotic resistance | RER1, HRH4, HRH1 | MAPT 2499/4885KMT2A 2701/4885MEN1 648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.