Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.68 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.32 |
| ▸ | TYMP | P19971 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Uracil SCHEMBL8202840 | 0.87 | CRBN (0.81) | CRBNMMP2TP53GPR84PDE3B | |
| Uracil SCHEMBL28545502 | 0.83 | CRBN (0.74) | CRBNMMP2TP53GPR84PDE3B | |
| Uracil SCHEMBL3798527 | 0.82 | CRBN (1.00) | CRBNMMP2TP53SMN1; SMN2TSHR | |
| Uracil SCHEMBL8235 | 0.82 | — | — | |
| Uracil SCHEMBL11607890 | 0.82 | — | — | |
| Uracil SCHEMBL5089507 | 0.82 | — | — | |
| Uracil SCHEMBL28426792 | 0.81 | CRBN (0.85) | CRBNMMP2TP53PDE3BPDE3A | |
| Uracil SCHEMBL28867999 | 0.81 | CRBN (0.85) | CRBNMMP2TP53SMN1; SMN2TSHR | |
| Uracil SCHEMBL2161716 | 0.80 | — | — | |
| Uracil SCHEMBL4664232 | 0.80 | CRBN (0.94) | CRBNMMP2TP53SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4067982-A | LOWERING BLOOD PRESSURE, ANALGESIC, SEDATIVE, ANTIHISTAMINE | Gulden, Byk (DT) | 1978-01-10 | — | — | US | disclosed |
| US-4067982-A | LOWERING BLOOD PRESSURE, ANALGESIC, SEDATIVE, ANTIHISTAMINE | Gulden, Byk (DT) | 1978-01-10 | — | — | US | disclosed |
| US-3957786-A | HYPOTENSIVE AGENTS | BYK GULDEN (DT) | 1976-05-18 | — | — | US | disclosed |
| US-3957786-A | HYPOTENSIVE AGENTS | BYK GULDEN (DT) | 1976-05-18 | — | — | US | disclosed |