SCHEMBL11670845

SCHEMBL11670845

COC(=O)C(C#N)CCC(C#N)C(=O)OC

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
SMN1; SMN2 Q16637 4/20 0.37
ZDHHC7 Q9NXF8 1/20 0.35
ANPEP P15144 4/20 0.33
TSHR P16473 3/20 0.33
ALDH1A1 P00352 2/20 0.33
MAPK1 P28482 1/20 0.33
CASP7 P55210 1/20 0.33
CA14 Q9ULX7 2/20 0.32
CHRNB2 P17787 1/20 0.31
CHRNB4 P30926 1/20 0.31
CHRNA3 P32297 1/20 0.31
CHRNA4 P43681 1/20 0.31
CA12 O43570 1/20 0.30
KMT2A Q03164 1/20 0.30
MCL1 Q07820 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10456812 0.89 CA1 (0.34) CA1CA2SMN1; SMN2ZDHHC7ANPEP
SCHEMBL10526563 0.89 CA1 (0.42) CA1CA2SMN1; SMN2ZDHHC7ANPEP
SCHEMBL8685379 0.87 TSHR (0.40) CA1CA2SMN1; SMN2ZDHHC7ANPEP
SCHEMBL7039726 0.87 CA1 (0.33) CA1CA2SMN1; SMN2ZDHHC7ANPEP
SCHEMBL7043093 0.86 CA1 (0.36) CA1CA2SMN1; SMN2ZDHHC7ANPEP
SCHEMBL7043088 0.86 CA1 (0.36) CA1CA2SMN1; SMN2ZDHHC7ANPEP
SCHEMBL8684831 0.86 CA2 (0.53) CA1CA2ZDHHC7TSHRALDH1A1
SCHEMBL8685566 0.86 TSHR (0.44) CA1CA2ZDHHC7TSHRALDH1A1
SCHEMBL16866506 0.84
SCHEMBL15268831 0.84

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4013524-A Electrolytic carboxylation and dimerization of olefins MONSANTO COMPANY (US) 1977-03-22 US disclosed