Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 3/20 | 0.57 |
| ▸ | CDK1 | P06493 | 3/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.57 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.57 |
| ▸ | JAK1 | P23458 | 6/20 | 0.54 |
| ▸ | TYK2 | P29597 | 6/20 | 0.54 |
| ▸ | JAK2 | O60674 | 4/20 | 0.54 |
| ▸ | JAK3 | P52333 | 4/20 | 0.54 |
| ▸ | F2 | P00734 | 6/20 | 0.53 |
| ▸ | F12 | P00748 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KLK7 | P49862 | 1/20 | 0.50 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | STK25 | O00506 | 1/20 | 0.47 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1167320 | 0.94 | CCNB2 (0.62) | CCNB2CDK1CCNB1CCNB3JAK1 | |
| SCHEMBL1248356 | 0.88 | CCNB2 (0.65) | CCNB2CDK1CCNB1CCNB3JAK1 | |
| SCHEMBL5986060 | 0.85 | CCNB2 (0.79) | CCNB2CDK1CCNB1CCNB3JAK1 | |
| SCHEMBL1167961 | 0.81 | CCNB2 (0.62) | CCNB2CDK1CCNB1CCNB3JAK1 | |
| SCHEMBL7092945 | 0.79 | CCNB2 (0.71) | CCNB2CDK1CCNB1CCNB3JAK1 | |
| SCHEMBL1168520 | 0.79 | NPC1 (0.52) | CCNB2CDK1CCNB1CCNB3JAK1 | |
| SCHEMBL1248143 | 0.78 | CCNB2 (0.77) | CCNB2CDK1CCNB1CCNB3JAK1 | |
| SCHEMBL1250715 | 0.77 | TYK2 (0.62) | CCNB2CDK1CCNB1CCNB3JAK1 | |
| SCHEMBL1167536 | 0.77 | CCNB2 (0.58) | CCNB2CDK1CCNB1CCNB3JAK1 | |
| SCHEMBL1250806 | 0.76 | CCNB2 (0.67) | CCNB2CDK1CCNB1CCNB3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070213375-A1 | Triazole derivatives useful as Axl inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2007-09-13 | — | — | US | claimed |
| US-8389557-B2 | Triazole derivatives useful as Axl inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2013-03-05 | — | — | US | disclosed |
| US-20110082131-A1 | TRIAZOLE DERIVATIVES USEFUL AS AXL INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | US | disclosed |
| US-7884119-B2 | protein tyrosine kinase receptor inhibitors such as 3-amino -1-(1H-indol-5-yl)carbonyl-5-[4-2-(pyrrolidin-1-yl)ethoxy]phenylamino]-1H-1,2,4-triazole, used for treating diseases and conditions associated with neovascularization and/or cell proliferation | RIGEL PHARMACEUTICALS, INC. (US) | 2011-02-08 | — | — | US | disclosed |
| EP-1922310-A2 | TRIAZOLE DERIVATIVES USEFUL AS AXL INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2008-05-21 | — | — | EP | disclosed |
| US-20070213375-A1 | Triazole derivatives useful as Axl inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2007-09-13 | — | — | US | disclosed |
| WO-2007030680-A2 | TRIAZOLE DERIVATIVES USEFUL AS AXL INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2007-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110082131-A1 | TRIAZOLE DERIVATIVES USEFUL AS AXL INHIBITORS | AXL, TYRO3, FLT3 | CCNB2 1915/4885CDK1 202/4885CCNB1 2575/4885 |
| US-20070213375-A1 | Triazole derivatives useful as Axl inhibitors | AXL, TYRO3, FLT3 | CCNB2 2510/4885CDK1 307/4885CCNB1 2980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.