SCHEMBL11675583

SCHEMBL11675583

Cn1nc(-c2ccccc2)c(Br)c1-c1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.54
CA2 P00918 1/20 0.54
MEN1 O00255 1/20 0.50
MAPT P10636 1/20 0.50
MAPK1 P28482 1/20 0.50
CASP1 P29466 1/20 0.50
BRCA1 P38398 1/20 0.50
HTT P42858 1/20 0.50
CASP7 P55210 1/20 0.50
KMT2A Q03164 1/20 0.50
KEAP1 Q14145 1/20 0.50
NFE2L2 Q16236 1/20 0.50
HSD17B10 Q99714 1/20 0.50
PTGER1 P34995 1/20 0.44
RECQL P46063 2/20 0.44
BRD4 O60885 1/20 0.44
KDM4E B2RXH2 2/20 0.43
ALDH1A1 P00352 2/20 0.43
NSD3 Q9BZ95 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4158211 0.82 MAPT (0.49) CA1CA2MEN1MAPTMAPK1
SCHEMBL13860722 0.81 MAPT (0.51) CA1CA2MEN1MAPTMAPK1
SCHEMBL14039695 0.79 BRD4 (0.51) CA1CA2MEN1MAPTMAPK1
SCHEMBL10337766 0.78 MAPT (0.51) CA1CA2MEN1MAPTMAPK1
SCHEMBL5539530 0.78 KMT2A (0.51) CA1CA2MEN1MAPTMAPK1
SCHEMBL20678524 0.77 CA1 (0.56) CA1CA2MEN1KMT2APTGER1
SCHEMBL14039939 0.77 POLB (0.54) CA1CA2MEN1MAPTMAPK1
SCHEMBL15636198 0.77 BRD4 (0.42) CA1CA2MEN1MAPTMAPK1
SCHEMBL14039563 0.77 ALDH1A1 (0.47) CA1CA2MEN1MAPTMAPK1
SCHEMBL13736647 0.76 RECQL (0.51) CA1CA2MEN1MAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4058391-A 1,2-Dialkyl-3,4,5-trisubstituted pyrazolium salts as herbicidal agents AMERICAN CYANAMID COMPANY (US) 1977-11-15 US disclosed
US-4041046-A INTERMEDIATES FOR THE CORRESPONDING HERBICIDAL PYRAZOLIUM SALTS ON AMERICAN CYANAMID COMPANY (US) 1977-08-09 US disclosed
US-4009277-A 1,2-Dialkyl-3,4,5-trisubstituted pyrazolium salts as fungicidal agents AMERICAN CYANAMID COMPANY (US) 1977-02-22 US disclosed
US-4000301-A Fungicidal use of 4-alkoxypyrazoles AMERICAN CYANAMID COMPANY (US) 1976-12-28 US disclosed
US-3963742-A 1,2-Dialkyl-3,4,5-trisubstituted pyrazolium salts as herbicidal agents AMERICAN CYANAMID COMPANY (US) 1976-06-15 US disclosed