Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HTR1B | P28222 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11679593 | 0.90 | SIRT1 (0.55) | KMT2ASIRT1MAPTPOLBHSD17B10 | |
| SCHEMBL11680918 | 0.85 | SIRT1 (0.58) | KMT2ASIRT1DRD2MAPKAPK2 | |
| SCHEMBL1874857 | 0.84 | SIRT1 (0.79) | KMT2ASIRT1MAPTHSD17B10ALDH1A1 | |
| SCHEMBL1869208 | 0.84 | SIRT1 (0.79) | SIRT1MAPKAPK2 | |
| SCHEMBL11680074 | 0.84 | SIRT1 (0.57) | KMT2ASIRT1MAPTPOLBHSD17B10 | |
| SCHEMBL11681778 | 0.84 | SIRT1 (0.57) | KMT2ASIRT1DRD2MAPKAPK2 | |
| SCHEMBL11679707 | 0.84 | SIRT1 (0.57) | KMT2ASIRT1HSD17B10L3MBTL1KDM4E | |
| SCHEMBL11679003 | 0.84 | MEN1 (0.67) | KMT2ASIRT1MAPTPOLBHSD17B10 | |
| SCHEMBL11680034 | 0.83 | SIRT1 (0.77) | SIRT1MAPKAPK2 | |
| SCHEMBL11680029 | 0.83 | SIRT1 (0.77) | SIRT1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4009181-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1977-02-22 | — | — | US | disclosed |